@prefix dce: <http://purl.org/dc/elements/1.1/>.
@prefix owl: <http://www.w3.org/2002/07/owl#>.
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
@prefix skos: <http://www.w3.org/2004/02/skos/core#>.
@prefix agent: <http://eulersharp.sourceforge.net/2003/03swap/agent#>.
@prefix clisko: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>.
@prefix drug: <http://www.agfa.com/w3c/2009/drugTherapy#>.
@prefix chemo: <http://www.agfa.com/w3c/2009/chemotherapy#>.
@prefix immusupther: <http://www.agfa.com/w3c/2009/immunosuppressiveTherapy#>.
@prefix antineo: <http://www.agfa.com/w3c/2009/antineoplastics#>.

<http://www.agfa.com/w3c/2009/antineoplastics>
	a owl:Ontology;
	dce:title """Antineoplastics"""@en;
	dce:creator """Hans Cools, MD; Agfa Healthcare/Belgium"""@en;
	dce:publisher """Agfa Healthcare/Belgium"""@en;
	dce:description """Formal general description of antineoplastics as applied in human medicine."""@en;
	dce:format """OWL Full"""@en;
	rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group / Ghent University - IBBT/ELIS - Multimedia Lab All Rights Reserved THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group/ Ghent University - IBBT/ELIS - Multimedia Lab The copyright notice above does not evidence any actual or intended publication of such source code."""@en.

#
# CLASSES
#

antineo:Methotrexate
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """methotrexate"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:FolicAcidAnalogue, [
		a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom immusupther:Immunosuppressant];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01BA01"^^clisko:atc20090101DT].

antineo:Cladribine
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """cladribine"""@en;
	rdfs:subClassOf chemo:PurineAnalogue;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01BB04"^^clisko:atc20090101DT].

antineo:Fludarabine
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """fludarabine"""@en;
	rdfs:subClassOf chemo:PurineAnalogue;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01BB05"^^clisko:atc20090101DT].

antineo:Cytarabine
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """cytarabine"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:PyrimidineAnalogue;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01BC01"^^clisko:atc20090101DT].

antineo:Alemtuzumab
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """alemtuzumab"""@en;
	skos:definition """Humanized monoclonal antibody binding to a CD52-antigen on the surface of B- and T-lymphocytes."""@en;
	rdfs:subClassOf chemo:MonoclonalAntibody;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01XC04"^^clisko:atc20090101DT].

antineo:Rituximab
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """rituximab"""@en;
	skos:definition """Humanized monoclonal antibody binding to a CD20-antigen on the surface of B-lymphocytes."""@en;
	rdfs:subClassOf chemo:MonoclonalAntibody;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01XC02"^^clisko:atc20090101DT].

antineo:Carmustine
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """carmustine"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:Nitrosourea;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01AD01"^^clisko:atc20090101DT].

antineo:Cyclophosphamide
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """cyclophosphamide"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:NitrogenMustardAnalogue;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01AA01"^^clisko:atc20090101DT].

antineo:Chlorambucil
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """chlorambucil"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:NitrogenMustardAnalogue;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01AA02"^^clisko:atc20090101DT].

antineo:Melphalan
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """melphalan"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:NitrogenMustardAnalogue;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01AA03"^^clisko:atc20090101DT].

antineo:Trofosfamide
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """trofosfamide"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:NitrogenMustardAnalogue;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01AA07"^^clisko:atc20090101DT].

antineo:Bendamustin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """bendamustin"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:NitrogenMustardAnalogue;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01AA09"^^clisko:atc20090101DT].

antineo:Cisplatin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """cisplatin"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:PlatinumCompound;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01XA01"^^clisko:atc20090101DT].

antineo:Pentostatin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """pentostatin """@en;
	skos:definition """."""@en;
	rdfs:subClassOf [
		a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom chemo:Antineoplastic];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01XX08"^^clisko:atc20090101DT].

antineo:Doxorubicin 
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """doxorubicin"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:Anthracycline;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01DB01"^^clisko:atc20090101DT].

antineo:Epirubicin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """epirubicin"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:Anthracycline;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01DB03"^^clisko:atc20090101DT].

antineo:Mitoxantrone
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """mitoxantrone"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:Anthracenedione;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01DB07"^^clisko:atc20090101DT].

antineo:Etoposide
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """etoposide"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:PodophyllotoxinDerivative;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01CB01"^^clisko:atc20090101DT].

antineo:Vincristine
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antineoplastics#>;
	rdfs:label """vincristine"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf chemo:VincaAlkaloid;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "L01CA02"^^clisko:atc20090101DT].