@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>.
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
@prefix owl: <http://www.w3.org/2002/07/owl#>.
@prefix xsd: <http://www.w3.org/2001/XMLSchema#>.
@prefix dce: <http://purl.org/dc/elements/1.1/>.
@prefix skos: <http://www.w3.org/2004/02/skos/core#>.
@prefix foaf: <http://xmlns.com/foaf/0.1/>.
@prefix unit: <http://sweet.jpl.nasa.gov/2.3/reprSciUnits.owl#>.
@prefix mrela: <http://sweet.jpl.nasa.gov/2.3/relaMath.owl#>.
@prefix screla: <http://sweet.jpl.nasa.gov/2.3/relaSci.owl#>.
@prefix agent: <http://eulersharp.sourceforge.net/2003/03swap/agent#>.
@prefix event: <http://eulersharp.sourceforge.net/2003/03swap/event#>.
@prefix physical: <http://eulersharp.sourceforge.net/2003/03swap/physicalResource#>.
@prefix space: <http://eulersharp.sourceforge.net/2003/03swap/space#>.
@prefix humanbody: <http://eulersharp.sourceforge.net/2003/03swap/humanBody#>.
@prefix quant: <http://eulersharp.sourceforge.net/2003/03swap/quantities#>.
@prefix units: <http://eulersharp.sourceforge.net/2003/03swap/units#>.
@prefix clineva: <http://www.agfa.com/w3c/2009/clinicalEvaluation#>.
@prefix clinproc: <http://www.agfa.com/w3c/2009/clinicalProcedure#>.
@prefix clisko: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>.
@prefix hurifa: <http://www.agfa.com/w3c/2009/humanRiskFactors#>.
@prefix ther: <http://www.agfa.com/w3c/2009/therapy#>.
@prefix heca: <http://www.agfa.com/w3c/2009/healthCare#>.
@prefix clinobs: <http://www.agfa.com/w3c/2009/clinicalObservation#>.
@prefix dradfo: <http://www.agfa.com/w3c/2009/drugAdministrationForms#>.
@prefix drug: <http://www.agfa.com/w3c/2009/drugTherapy#>.
<http://www.agfa.com/w3c/2009/drugTherapy>
a owl:Ontology;
dce:title """Drug Therapy"""@en;
dce:creator """Hans Cools, MD; Agfa Healthcare/Belgium"""@en;
dce:contributor """Until 2010: Pieterjan De Potter; Ghent University - IBBT/ELIS - Multimedia Lab/Belgium"""@en;
dce:publisher """Agfa Healthcare/Belgium"""@en;
dce:description """Formal general description of clinical drug therapy."""@en;
dce:format """OWL-Full"""@en;
rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group and Ghent University - IBBT/ELIS - Multimedia Lab. All Rights Reserved. THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group and Ghent University - IBBT/ELIS - Multimedia Lab The copyright notice above does not evidence any actual or intended publication of such source code."""@en.
drug:Therapy
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug therapy"""@en;
skos:definition """Clinical therapy implying administration of a drug."""@en;
rdfs:subClassOf ther:Therapy, [
a owl:Restriction; owl:onProperty event:hasSubProcedure; owl:someValuesFrom drug:Administering];
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "416608005"^^clisko:sct20080731DT].
drug:Administering
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug administering"""@en;
skos:definition """Administering a clinical drug to a patient."""@en;
rdfs:subClassOf clinproc:SubstanceAdministering, [
a owl:Restriction; owl:onProperty event:hasObject; owl:someValuesFrom drug:AdministrationForm], [
a owl:Restriction; owl:onProperty quant:hasFrequency; owl:someValuesFrom drug:AdministeringFrequency], [
a owl:Restriction; owl:onProperty clinproc:whereinAdministered; owl:someValuesFrom drug:AdministrationForm], [
a owl:Restriction; owl:onProperty event:hasOutput; owl:someValuesFrom drug:Administration];
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "18629005"^^clisko:sct20080731DT].
drug:Administration
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug administration"""@en;
skos:definition """Output of clinical drug administering."""@en;
rdfs:subClassOf [
a owl:Restriction; owl:onProperty event:outputOf; owl:someValuesFrom drug:Administering], [
a owl:Restriction; owl:onProperty clinproc:administrationOf; owl:someValuesFrom drug:AdministrationForm].
drug:Substance
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug substance"""@en;
skos:definition """Substance, when absorbed into a patient's body, aims at restoring a function or preventing a deterioration."""@en;
rdfs:subClassOf clinproc:Substance, agent:DrugSubstance, [
a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom drug:Role];
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "410942007"^^clisko:sct20080731DT].
drug:Role
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug role"""@en;
skos:definition """Role of a clinical drug substance."""@en;
rdfs:subClassOf ther:TherapeuticRole, clinproc:PreventiveRole, clineva:DiagnosticRole, [
a owl:Restriction; owl:onProperty agent:rolePlayedBy; owl:someValuesFrom drug:Substance].
drug:ExperimentalSubstance
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """experimental clinical drug"""@en;
skos:definition """Substance used as drug in an experimental clinical setting."""@en;
rdfs:subClassOf drug:Substance;
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "902003"^^clisko:sct20080731DT].
drug:Concentration
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug strength"""@en;
skos:definition """Concentration of a clinical drug as active substance in an administration form."""@en;
rdfs:subClassOf quant:Concentration.
drug:Product
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug product"""@en;
skos:definition """Clinical drug as suitable for administration."""@en;
rdfs:comment """Clinical drug usually produced by a pharmaceutical company."""@en;
skos:note """A placebo does not contain a known active part."""@en;
rdfs:subClassOf physical:Product, physical:Compound, [
a owl:Restriction; owl:onProperty space:containedBy; owl:someValuesFrom drug:AdministrationForm].
drug:Excipient
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug product excipient"""@en;
skos:definition """Substance added to a clinical drug product, having an effect other than a clinical drug substance; cf http://www.agfa.com/w3c/2009/drugExcipients#."""@en;
skos:note """cf http://www.agfa.com/w3c/2009/drugExcipients#."""@en;
rdfs:subClassOf clinproc:Substance.
drug:ExcipientRole
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug product excipient role"""@en;
skos:definition """Role of a clinical drug product excipient."""@en;
rdfs:subClassOf agent:Role.
drug:Compound
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug compound"""@en;
skos:definition """Clinical drug product containing more than 1 active substance."""@en;
rdfs:subClassOf drug:Product, [
a owl:Restriction; owl:onProperty drug:hasActivePart; owl:minCardinality "2"^^xsd:nonNegativeInteger].
drug:AdministrationForm
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug administration form"""@en;
skos:definition """Form in which a clinical drug product is administered."""@en;
rdfs:subClassOf physical:Product, clinproc:AdministrableSubstance, [
a owl:Restriction; owl:onProperty space:contains; owl:someValuesFrom drug:Product];
skos:exactMatch [
a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "421967003"^^clisko:sct20080731DT].
drug:Package
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug package"""@en;
skos:definition """Clinical drug as available for purchase."""@en;
rdfs:subClassOf physical:Product, [
a owl:Restriction; owl:onProperty space:contains; owl:someValuesFrom drug:PackageUnit].
drug:CombiPackage
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug combination package"""@en;
skos:definition """Clinical drug package containing more than 1 administration form, each in its own package."""@en;
rdfs:subClassOf physical:Product, [
a owl:Restriction; owl:onProperty space:contains; owl:someValuesFrom drug:Package], [
a owl:Restriction; owl:onProperty space:contains; owl:minCardinality "2"^^xsd:nonNegativeInteger].
drug:PackageUnit
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug package unit"""@en;
skos:definition """Individually packaged clinical drug administration form unit."""@en;
rdfs:comment """E.g. tablet, ampoule, infusion bag, bottle."""@en;
rdfs:subClassOf physical:Product, [
a owl:Restriction; owl:onProperty space:contains; owl:someValuesFrom drug:AdministrationForm].
drug:PackageUnitQuantity
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug package unit quantity"""@en;
skos:definition """Quantity in which a clinical drug administration form is available."""@en;
rdfs:comment """E.g. an injection solution available in 3 milliliter."""@en;
rdfs:subClassOf [owl:disjointUnionOf (quant:Mass quant:Volume drug:AdministrationFormQuantity)].
drug:Monotherapy
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """monodrug therapy"""@en;
skos:definition """Clinical therapy implying administration of 1 drug at a time."""@en;
rdfs:subClassOf drug:Therapy.
drug:Polytherapy
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """polydrug therapy"""@en;
skos:definition """Clinical therapy implying administration of 2 or more drugs simultaneously."""@en;
rdfs:subClassOf drug:Therapy.
drug:Dosage
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug dosage"""@en;
skos:definition """Clinical drug administration form dosed in a quantity, as output of clinical drug dosing, given at one time."""@en;
rdfs:comment """E.g. 3 (x 1) tablets, 3 x 5 ml sirup (= 3 tsp sirup)."""@en.
drug:DosageQuantity
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug administration form dosage quantity"""@en;
skos:definition """Quantity in which a clinical drug administration form is dosed."""@en;
rdfs:comment """E.g. 3 (x 1) tablets, 3 x 5 ml (= 3 tsp) (sirup)."""@en;
rdfs:subClassOf [owl:disjointUnionOf (quant:Mass quant:Volume drug:AdministrationFormQuantity)].
drug:AdministrationFormQuantity
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug administration form quantity"""@en;
skos:definition """Quantity of a drug administration form of which the unit is the drug administration form itself."""@en;
rdfs:comment """E.g. 3 tablets."""@en;
rdfs:subClassOf quant:PhysicalQuantity, [
a owl:Restriction; owl:onProperty quant:hasMeasurement; owl:allValuesFrom [
a owl:Restriction; owl:onProperty quant:hasUnit; owl:someValuesFrom drug:administrationFormUnit]].
drug:AdministeringFrequency
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug administering frequency"""@en;
skos:definition """Frequency of clinical drug administering."""@en;
rdfs:subClassOf quant:Frequency, [
a owl:Restriction; owl:onProperty quant:frequencyOf; owl:someValuesFrom drug:Administering].
drug:Prescribing
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug prescribing"""@en;
skos:definition """Clinical prescribing, describing one or more drugs and how to administer them."""@en;
rdfs:subClassOf clinproc:Prescribing, [
a owl:Restriction; owl:onProperty event:hasOutput; owl:allValuesFrom drug:Prescription].
drug:Prescription
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug prescription"""@en;
skos:definition """Clinical prescription as outcome of clinical drug prescribing."""@en;
rdfs:comment """E.g. R/ Glucophage 500 mg; DT/ 1 package 60 tablets; S/ 3 x 1 tablet/day."""@en;
rdfs:subClassOf clinproc:Prescription, [
a owl:Restriction; owl:onProperty event:outputOf; owl:someValuesFrom drug:Prescribing], [
a owl:Restriction; owl:onProperty clinproc:whereinPrescribed; owl:someValuesFrom drug:Package], [
a owl:Restriction; owl:onProperty clinproc:whereinPrescribed; owl:someValuesFrom drug:Dosage], [
a owl:Restriction; owl:onProperty clinproc:whereinPrescribed; owl:someValuesFrom drug:AdministeringFrequency].
drug:Delivering
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug delivering"""@en;
skos:definition """Pharmacist handing over a clinical drug to a patient."""@en;
rdfs:subClassOf event:Delivering, clinproc:Procedure, [
a owl:Restriction; owl:onProperty agent:hasDonor; owl:someValuesFrom heca:Pharmacist], [
a owl:Restriction; owl:onProperty agent:hasRecipient; owl:someValuesFrom heca:Patient], [
a owl:Restriction; owl:onProperty event:hasOutput; owl:allValuesFrom drug:Delivery].
drug:Delivery
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug delivered"""@en;
skos:definition """Clinical drug handed over by a pharmacist to a patient."""@en;
rdfs:subClassOf event:Delivery, [
a owl:Restriction; owl:onProperty event:outputOf; owl:someValuesFrom drug:Delivering], [
a owl:Restriction; owl:onProperty event:whereinDelivered; owl:someValuesFrom drug:Package].
drug:DeliveryCondition
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug delivery condition"""@en;
skos:definition """Condition to be satisfied in order for a clinical drug to be delivered."""@en;
rdfs:subClassOf event:Condition.
drug:AdverseReaction
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """adverse drug reaction"""@en;
skos:definition """An adverse reaction associated with the use of a clinical drug at a normal dose."""@en;
rdfs:subClassOf hurifa:RiskFactor;
skos:exactMatch [
a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "106190000"^^clisko:sct20080731DT], [
a skos:Concept; skos:inScheme clisko:icpc2; skos:notation "A85"^^clisko:icpc2DT], [
a skos:Concept; skos:inScheme clisko:icd10; skos:notation "T88.7"^^clisko:icd10DT].
drug:MarketState
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug market state"""@en;
skos:definition """State of a clinical drug on the pharmaceutical market."""@en;
owl:oneOf (drug:onMarket drug:outOfMarket drug:pulledOffMarket drug:marketStateUnknown drug:pulledOffMarketByCompany drug:approvalSuspended).
drug:Immunisation
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """immunisation"""@en;
skos:definition """Making a human body immune to a pathogen."""@en;
owl:intersectionOf (clinproc:PrimaryPreventing drug:Therapy);
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "127785005"^^clisko:sct20080731DT].
drug:ActiveImmunisation
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """active immunisation"""@en;
skos:definition """Making a human body immune by letting it form antibodies to a pathogen."""@en;
rdfs:subClassOf drug:Immunisation;
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "33879002"^^clisko:sct20080731DT].
drug:Interacting
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """drug interacting"""@en;
skos:definition """An interacting involving 2 or more agents of which at least 1 is a clinical drug."""@en;
skos:note """Not limited to direct interaction between agents."""@en;
rdfs:subClassOf clinproc:Interacting, [
a owl:Restriction; owl:onProperty agent:hasAgent; owl:someValuesFrom drug:Substance], [
a owl:Restriction; owl:onProperty event:hasOutput; owl:someValuesFrom drug:Interaction].
drug:Interaction
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """drug interaction"""@en;
skos:definition """Output of drug interacting."""@en;
rdfs:subClassOf event:Interaction, [
a owl:Restriction; owl:onProperty event:outputOf; owl:someValuesFrom drug:Interacting], [
a owl:Restriction; owl:onProperty event:hasObject; owl:someValuesFrom clinobs:Finding].
drug:InteractionState
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """interaction state"""@en;
skos:definition """State of a clinical drug interaction."""@en;
owl:oneOf (drug:interactionDocumented drug:interactionExpected drug:interactionUnlikely drug:interactionUnknown).
drug:administrationFormUnit
a units:Unit;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug administration form unit"""@en;
skos:definition """Clinical drug administration form as unit."""@en;
rdfs:comment """E.g. a tablet, a capsule."""@en;
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "408103002"^^clisko:sct20080731DT].
drug:milligramPerTablet
a units:Unit, unit:UnitDefinedByProduct;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """milligram per tablet"""@en;
skos:definition """Unit of a concentration of a clinical drug in mg in a tablet."""@en;
quant:unitOf [a owl:Restriction; owl:onProperty quant:measurementOf; owl:someValuesFrom quant:Concentration];
mrela:hasOperand units:milligram, drug:perTablet.
drug:milligramPerCapsule
a units:Unit, unit:UnitDefinedByProduct;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """milligram per capsule"""@en;
skos:definition """Unit of a concentration of a clinical drug in mg in a capsule."""@en;
quant:unitOf [a owl:Restriction; owl:onProperty quant:measurementOf; owl:someValuesFrom quant:Concentration];
mrela:hasOperand units:milligram, drug:perCapsule.
drug:perCapsule
a unit:UnitDerivedByRaisingToPower;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """per capsule"""@en;
skos:definition """Per capsule as unit of concentration."""@en;
mrela:toThePower "-1"^^xsd:double;
screla:hasBaseUnit dradfo:Capsule;
quant:unitOf [a owl:Restriction; owl:onProperty quant:measurementOf; owl:someValuesFrom quant:Concentration];
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "428641000"^^clisko:sct20080731DT].
drug:perTablet
a unit:UnitDerivedByRaisingToPower;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """per tablet"""@en;
skos:definition """Per tablet as unit of mass concentration."""@en;
mrela:toThePower "-1"^^xsd:double;
screla:hasBaseUnit dradfo:Tablet;
quant:unitOf [a owl:Restriction; owl:onProperty quant:measurementOf; owl:someValuesFrom quant:Concentration].
drug:freeOfPrescription
a drug:DeliveryCondition;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """free of prescription"""@en;
skos:definition """Clinical drug that can be delivered without the need of a prescription of a medical professional."""@en.
drug:subjectToPrescription
a drug:DeliveryCondition;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """subject to prescription"""@en;
skos:definition """Clinical drug that can be delivered only on prescription of a medical professional."""@en.
drug:narcoticDeliveryCondition
a drug:DeliveryCondition;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """narcotic delivery condition"""@en;
skos:definition """Narcotic clinical drug that can be delivered only on special prescription of a medical professional."""@en.
drug:subjectToPrescriptionWithExceptions
a drug:DeliveryCondition;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """subject to prescription with exceptions"""@en;
skos:definition """Clinical drug that can be delivered, with some exceptions, only on prescription of a medical professional."""@en.
drug:interactionDocumented
a drug:InteractionState;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """interaction documented"""@en;
skos:definition """ ."""@en.
drug:interactionExpected
a drug:InteractionState;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """interaction expected"""@en;
skos:definition """ ."""@en.
drug:interactionUnknown
a drug:InteractionState;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """interaction unknown"""@en;
skos:definition """ ."""@en.
drug:interactionUnlikely
a drug:InteractionState;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """interaction unlikely"""@en;
skos:definition """ ."""@en.
drug:onMarket
a drug:MarketState;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug on market"""@en;
skos:definition """Clinical drug present on the pharmaceutical market."""@en.
drug:outOfMarket
a drug:MarketState;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug out of market"""@en;
skos:definition """Clinical drug absent from the pharmaceutical market."""@en.
drug:pulledOffMarket
a drug:MarketState;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug pulled off market"""@en;
skos:definition """Clinical drug pulled off the pharmaceutical market."""@en.
drug:pulledOffMarketByCompany
a drug:MarketState;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug pulled off market by company"""@en;
skos:definition """Clinical drug pulled off the pharmaceutical market by the producing pharmaceutical company."""@en.
drug:approvalSuspended
a drug:MarketState;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug approval suspended"""@en;
skos:definition """Clinical drug of which the approval for marketing has been suspended."""@en.
drug:marketStateUnknown
a drug:MarketState;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
rdfs:label """clinical drug market state unknown"""@en;
skos:definition """Clinical drug of which the market state is unknown."""@en.
drug:whereinAdministered
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a drug administered in a clinical therapy."""@en;
owl:propertyChainAxiom (event:hasSubProcedure clinproc:whereinAdministered space:contains drug:hasActivePart);
rdfs:domain drug:Therapy;
rdfs:range drug:Substance.
drug:hasGenericName
a rdf:Property;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a generic name of a clinical drug."""@en;
rdfs:subPropertyOf foaf:name;
rdfs:domain drug:Substance;
rdfs:range rdfs:Literal.
drug:hasConcentration
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a concentration or 'strength' of a drug substance."""@en;
rdfs:subPropertyOf quant:hasPhysicalQuantity;
rdfs:domain drug:Substance;
rdfs:range drug:Concentration.
drug:hasActivePart
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a clinical drug as active part of a drug product."""@en;
rdfs:subPropertyOf clinproc:hasActivePart;
rdfs:domain drug:Product;
rdfs:range drug:Substance.
drug:activePartOf
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a drug product containing a clinical drug as active part."""@en;
owl:inverseOf drug:hasActivePart;
rdfs:domain drug:Substance;
rdfs:range drug:Product.
drug:hasExcipient
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a non active part of a drug product."""@en;
rdfs:subPropertyOf space:contains;
rdfs:domain drug:Product;
rdfs:range drug:Excipient.
drug:excipientOf
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a drug product containing a non active part."""@en;
rdfs:subPropertyOf space:containedBy;
owl:inverseOf drug:hasExcipient;
rdfs:domain drug:Excipient;
rdfs:range drug:Product.
drug:hasUnitsPerPackage
a owl:DatatypeProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying the number of drug administration form units in a package."""@en;
rdfs:domain drug:AdministrationForm;
rdfs:range xsd:nonNegativeInteger.
drug:hasAdministrationForm
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying an administration form of a clinical drug dosage."""@en;
rdfs:domain drug:Dosage;
rdfs:range drug:AdministrationForm.
drug:administrationFormOf
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a clinical drug dosage having a clinical drug administration form."""@en;
owl:inverseOf drug:hasAdministrationForm;
rdfs:domain drug:AdministrationForm;
rdfs:range drug:Dosage.
drug:hasDosage
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a clinical drug dosage of an administration."""@en;
rdfs:domain drug:Administration;
rdfs:range drug:Dosage.
drug:dosageOf
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying an administration of a clinical drug dosage."""@en;
owl:inverseOf drug:hasDosage;
rdfs:domain drug:Dosage;
rdfs:range drug:Administration.
drug:hasDosageQuantity
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying an administration form quantity of a clinical drug dosage."""@en;
rdfs:subPropertyOf quant:hasPhysicalQuantity;
rdfs:domain drug:Dosage;
rdfs:range drug:DosageQuantity.
drug:hasAdministrationSite
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a administration body site of a drug administration form as used in a clinical drug administering."""@en;
rdfs:domain drug:AdministrationForm;
rdfs:range humanbody:Structure.
drug:hasRefills
a owl:DatatypeProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a number of refills that can be done before a new prescription is needed."""@en;
rdfs:domain drug:Package;
rdfs:range xsd:nonNegativeInteger.
drug:hasAdministrationInstructions
a rdf:Property;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying instructions for clinical drug administration."""@en;
rdfs:comment """E.g. '30 min before breakfast'."""@en;
rdfs:domain drug:Package;
rdfs:range rdfs:Literal.
drug:gotPrescribed
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a clinical drug package a patient got prescribed."""@en;
rdfs:subPropertyOf clinproc:gotPrescribed;
rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Patient];
rdfs:range drug:Package.
drug:prescribedFor
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a human patient that got a clinical drug package prescribed."""@en;
rdfs:subPropertyOf clinproc:prescribedFor;
rdfs:domain drug:Package;
rdfs:range [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Patient].
drug:hasMarketState
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying the market state of a clinical drug as commercially available."""@en;
rdfs:domain drug:Package;
rdfs:range drug:MarketState.
drug:hasDeliveryCondition
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying the delivery condition of a clinical drug as commercially available."""@en;
rdfs:domain drug:Package;
rdfs:range drug:DeliveryCondition.
drug:hasAffectedDrug
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a drug affected by another one with which it is interacting."""@en;
rdfs:domain drug:Interacting;
rdfs:range drug:Substance.
drug:hasAffectingDrug
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a drug affecting another one with which it is interacting."""@en;
rdfs:domain drug:Interacting;
rdfs:range drug:Substance.
drug:hasAffectedDrugInteractionState
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying an affected drug's interaction state."""@en;
rdfs:domain drug:Interacting;
rdfs:range drug:InteractionState.
drug:hasAffectingDrugInteractionState
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying an affecting drug's interaction state."""@en;
rdfs:domain drug:Interacting;
rdfs:range drug:InteractionState.
drug:affects
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a drug affecting another one in an interaction."""@en;
rdfs:domain drug:Substance;
rdfs:range drug:Substance.
drug:interactionOf
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/drugTherapy#>;
skos:definition """Specifying a drug of an interaction."""@en;
rdfs:domain drug:Interaction;
rdfs:range drug:Substance.