@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
@prefix owl: <http://www.w3.org/2002/07/owl#>.
@prefix xsd: <http://www.w3.org/2001/XMLSchema#>.
@prefix dce: <http://purl.org/dc/elements/1.1/>.
@prefix dct: <http://purl.org/dc/terms/>.
@prefix skos: <http://www.w3.org/2004/02/skos/core#>.
@prefix agent: <http://eulersharp.sourceforge.net/2003/03swap/agent#>.
@prefix event: <http://eulersharp.sourceforge.net/2003/03swap/event#>.
@prefix clineva: <http://www.agfa.com/w3c/2009/clinicalEvaluation#>.
@prefix clinproc: <http://www.agfa.com/w3c/2009/clinicalProcedure#>.
@prefix clinobs: <http://www.agfa.com/w3c/2009/clinicalObservation#>.
@prefix clisko: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>.
@prefix heca: <http://www.agfa.com/w3c/2009/healthCare#>.
@prefix humdis: <http://www.agfa.com/w3c/2009/humanDisorder#>.
@prefix ther: <http://www.agfa.com/w3c/2009/therapy#>.
<http://www.agfa.com/w3c/2009/therapy#>
a owl:Ontology;
dce:title """Therapy"""@en;
dce:creator """Hans Cools, MD, Agfa Healthcare/Belgium"""@en;
dce:contributor """Until 2010: Pieterjan De Potter, Pedro Debevere, Ghent University - IBBT/ELIS - Multimedia Lab/Belgium"""@en;
dce:publisher """Agfa Healthcare/Belgium"""@en;
dce:description """General description of clinical therapy."""@en;
dce:format """OWL Full"""@en;
rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group and Ghent University - IBBT/ELIS - Multimedia Lab. All Rights Reserved. THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group and Ghent University - IBBT/ELIS - Multimedia Lab The copyright notice above does not evidence any actual or intended publication of such source code."""@en.
ther:Therapy
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """clinical therapy"""@en;
skos:definition """An attempted remediation of a human health problem."""@en;
rdfs:subClassOf clinproc:Procedure, [
a owl:Restriction; owl:onProperty event:hasInput; owl:someValuesFrom [owl:disjointUnionOf (clineva:Diagnosis clineva:AbsentDiagnosis)]], [
a owl:Restriction; owl:onProperty event:after; owl:someValuesFrom clineva:Diagnosing];
skos:exactMatch [
a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "277132007"^^clisko:sct20080731DT].
ther:Monotherapy
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """monotherapy"""@en;
skos:definition """Applying 1 clinical therapy at a time."""@en;
rdfs:subClassOf ther:Therapy.
ther:Polytherapy
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """polytherapy"""@en;
skos:definition """Applying 2 or more therapies simultaneously."""@en;
rdfs:subClassOf ther:Therapy;
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "229554006"^^clisko:sct20080731DT].
ther:Intent
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """therapeutic intent"""@en;
skos:definition """Intended effect of a clinical therapy on the evolution of a disorder."""@en;
rdfs:subClassOf event:Intent;
owl:oneOf (ther:Curative ther:Ameliorative ther:Stabilizing).
ther:Protocol
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:subClassOf clinproc:Pathway;
skos:definition """Binding instructions for a therapy"""@en.
ther:Cycle
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """therapy cycle"""@en;
skos:definition """Cycle as a clinical therapy that can be repeated."""@en;
rdfs:comment """A clinical therapy can comprise a number of cycles. A cycle can comprise subprocedures, e.g. administrations of different drugs."""@en;
rdfs:subClassOf ther:Therapy.
ther:Substance
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """therapeutic substance"""@en;
skos:definition """Substance having a therapeutic effect."""@en;
rdfs:subClassOf clinproc:Substance.
ther:TherapeuticRole
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """therapeutic role"""@en;
skos:definition """Role of anything applied in a clinical therapy."""@en;
rdfs:subClassOf agent:Role.
ther:TestedTherapeuticRole
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """tested therapeutic role"""@en;
skos:definition """Therapeutic role confirmed in a test setting."""@en;
rdfs:subClassOf ther:TherapeuticRole.
ther:CausalTherapy
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """causal therapy"""@en;
skos:definition """Therapy having effect on the cause of a disease."""@en;
rdfs:subClassOf ther:Therapy;
rdfs:subClassOf [a owl:Restriction; owl:onProperty event:hasInput; owl:someValuesFrom clineva:CertainDiagnosis].
ther:NonCausalTherapy
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """noncausal therapy"""@en;
skos:definition """Therapy having no effect on the cause of a disease."""@en;
rdfs:subClassOf ther:Therapy.
ther:BlindTherapy
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """blind therapy"""@en;
skos:definition """Therapy started without knowing the cause of a disorder and/or the effect of a therapy."""@en;
rdfs:subClassOf ther:Therapy
.
ther:EmpiricalTherapy
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """empirical therapy"""@en;
skos:definition """Therapy started assuming possible effect based on experience (e.g. statistics) from similar cases."""@en;
rdfs:subClassOf ther:Therapy;
rdfs:subClassOf [a owl:Restriction; owl:onProperty event:hasOutputLikelihood; owl:hasValue event:Likely];
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "371018001"^^clisko:sct20080731DT].
ther:TargetedTherapy
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """targeted therapy"""@en;
skos:definition """Therapy wherein something is applied having a tested therapeutic role."""@en;
rdfs:subClassOf ther:Therapy, [
a owl:Restriction; owl:onProperty agent:hasAgent; owl:someValuesFrom [
a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom ther:TestedTherapeuticRole]], [
a owl:Restriction; owl:onProperty event:hasOutputLikelihood; owl:hasValue event:MostLikely].
ther:ExperimentalTherapy
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """experimental therapy"""@en;
skos:definition """Therapy wherein something is applied having an experimental therapeutic role."""@en;
rdfs:subClassOf ther:Therapy, [a owl:Restriction; owl:onProperty event:hasState; owl:someValuesFrom event:Experimental].
ther:Device
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """therapy device"""@en;
skos:definition """Device used in a clinical therapy."""@en;
rdfs:subClassOf heca:Device.
ther:Drain
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """drain"""@en;
rdfs:subClassOf ther:Device;
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "32712000"^^clisko:sct20080731DT].
ther:IntracerebralDrain
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """intracerebral drain"""@en;
rdfs:subClassOf ther:Drain;
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "258645009"^^clisko:sct20080731DT].
ther:EvacuationProcedure
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """evacuation procedure"""@en;
rdfs:subClassOf ther:Therapy;
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "122461007"^^clisko:sct20080731DT].
ther:DrainageProcedure
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """drainage procedure"""@en;
rdfs:subClassOf ther:EvacuationProcedure;
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "122462000"^^clisko:sct20080731DT].
ther:LumbarPunctureToLowerIntracranialPressure
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """lumbar puncture to lower intracranial pressure"""@en;
rdfs:subClassOf ther:DrainageProcedure;
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "231062004"^^clisko:sct20080731DT].
ther:Surgery
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """clinical surgery"""@en;
skos:definition """Clinical therapy involving opening the coverage (skin, cornea, mucosa, etc) of a human body."""@en;
rdfs:subClassOf ther:Therapy;
skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "387713003"^^clisko:sct20080731DT].
ther:OtherSurgeryThanSplenectomy
skos:note """Just to show how far modelling can go :), created for a specific research project GUI."""@en;
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """other surgery than splenectomy"""@en;
rdfs:subClassOf ther:Surgery.
ther:Response
a rdfs:Class;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """clinical therapy response"""@en;
skos:definition """Response of a human health disorder to a clinical therapy."""@en.
ther:Curative
a rdfs:Class, ther:Intent;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """curative"""@en;
skos:definition """Freeing of a health affliction."""@en.
ther:Ameliorative
a rdfs:Class, ther:Intent;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """ameliorative"""@en;
skos:definition """Lessening a health affliction."""@en.
ther:Stabilizing
a rdfs:Class, ther:Intent;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """stabilizing"""@en;
skos:definition """Stabilizing a health affliction."""@en.
ther:Residual
a rdfs:Class, ther:Response;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """residual"""@en;
skos:definition """State of a human health disorder remaining after therapy."""@en;
rdfs:subClassOf humdis:Residual.
ther:treatedWith
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical therapy wherewith a clinical finding is treated."""@en;
rdfs:domain clinobs:Finding;
rdfs:range ther:Therapy.
ther:maintainedWith
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical therapy wherewith a clinical finding is maintained."""@en;
rdfs:domain clinobs:Finding;
rdfs:range ther:Therapy.
ther:firstTreatedWith
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """first treated with"""@en;
skos:definition """Specifying a primary clinical therapy wherewith a clinical finding is treated."""@en;
skos:note """Used in an N3 rule to establish this relation."""@en;
rdfs:domain clinobs:Finding;
rdfs:range ther:Therapy.
ther:secondarilyTreatedWith
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
rdfs:label """secondarily treated with"""@en;
skos:definition """Specifying a secondary clinical therapy wherewith a clinical finding is treated."""@en;
skos:note """Used in an N3 rule to establish this relation."""@en;
rdfs:domain clinobs:Finding;
rdfs:range ther:Therapy.
ther:notTreatedWith
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical therapy not used for treating a clinical finding."""@en;
rdfs:domain clinobs:Finding;
rdfs:range ther:Therapy.
ther:usedToTreat
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical finding treated with a clinical therapy."""@en;
rdfs:domain ther:Therapy;
rdfs:range clinobs:Finding.
ther:treatedBy
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a health care professional treating a patient."""@en;
rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Patient];
rdfs:range [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Professional].
ther:treats
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a patient treated by a health care professional."""@en;
owl:inverseOf ther:treatedBy;
rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Professional];
rdfs:range [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Patient].
ther:treatedIn
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a therapy wherein a patient is treated."""@en;
rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Patient];
rdfs:range ther:Therapy.
ther:whereinTreated
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a patient treated in a therapy."""@en;
owl:inverseOf ther:treatedIn;
rdfs:domain ther:Therapy;
rdfs:range [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Patient].
ther:hasIntent
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a therapeutic intent of a clinical therapy."""@en;
rdfs:subPropertyOf event:hasIntent;
rdfs:domain ther:Therapy;
rdfs:range ther:Intent.
ther:hasNumberOfCycles
a owl:DatatypeProperty, owl:FunctionalProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a number of cycles of a clinical therapy."""@en;
rdfs:domain ther:Therapy;
rdfs:range xsd:decimal.
ther:hasTherapyResponse
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a response of a human health disorder to a clinical therapy."""@en;
owl:propertyChainAxiom (ther:treatedWith ther:wheretoResponse);
rdfs:domain humdis:Disorder;
rdfs:range humdis:State.
ther:therapyResponseOf
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a human health disorder having a response to a clinical therapy."""@en;
owl:propertyChainAxiom (ther:responseTo ther:usedToTreat);
rdfs:domain humdis:State;
rdfs:range humdis:Disorder.
ther:responseTo
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical therapy whereto of a human health disorder has a response."""@en;
rdfs:subPropertyOf event:outputOf;
owl:propertyChainAxiom (humdis:stateOf ther:treatedWith);
rdfs:domain humdis:State;
rdfs:range ther:Therapy.
ther:wheretoResponse
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a response of a human health disorder to a clinical therapy."""@en;
rdfs:subPropertyOf event:hasOutput;
owl:propertyChainAxiom (ther:usedToTreat humdis:hasState);
rdfs:domain ther:Therapy;
rdfs:range humdis:State.
ther:hasResponseTo
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical therapy a human health disorder has a response to."""@en;
owl:propertyChainAxiom (ther:hasTherapyResponse ther:responseTo);
rdfs:domain humdis:Disorder;
rdfs:range ther:Therapy.
ther:hasCompleteRemissionAfter
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical therapy whereafter a human health disorder has a complete remission."""@en;
rdfs:subPropertyOf ther:hasResponseTo;
rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:CompleteRemission];
rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:CompleteRemission].
ther:hasCompleteRemissionIPNAfter
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical therapy whereafter a human health disorder has a complete remission with insufficient platelets or neutrophils recovery."""@en;
rdfs:subPropertyOf ther:hasResponseTo;
rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:CompleteRemissionIPN];
rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:CompleteRemissionIPN].
ther:hasCompleteRemissionUnconfirmedAfter
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical therapy whereafter a human health disorder has an unconfirmed complete remission."""@en;
rdfs:subPropertyOf ther:hasResponseTo;
rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:CompleteRemissionUnconfirmed];
rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:CompleteRemissionUnconfirmed].
ther:hasPartialRemissionAfter
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical therapy whereafter a human health disorder has a partial remission."""@en;
rdfs:subPropertyOf ther:hasResponseTo;
rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:PartialRemission];
rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:PartialRemission].
ther:hasNodularPartialRemissionAfter
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical therapy whereafter a human health disorder has a nodular partial remission."""@en;
rdfs:subPropertyOf ther:hasResponseTo;
rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:NodularPartialRemission];
rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:NodularPartialRemission].
ther:stableAfter
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical therapy whereafter a human health disorder is stable."""@en;
rdfs:subPropertyOf ther:hasResponseTo;
rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:Stable];
rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:Stable].
ther:progressiveAfter
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a clinical therapy whereafter a human health disorder is progressive."""@en;
rdfs:subPropertyOf ther:hasResponseTo;
rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:Progressive];
rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:Progressive].
ther:replaces
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a therapy replaced by another for the same patient and disease."""@en;
skos:note """further formalization in an N3 rule."""@en;
rdfs:domain ther:Therapy;
rdfs:range ther:Therapy.
ther:addedTo
a owl:ObjectProperty;
rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
skos:definition """Specifying a therapy to which another is added for the same patient and disease."""@en;
skos:note """further formalization in an N3 rule."""@en;
rdfs:domain ther:Therapy;
rdfs:range ther:Therapy.