@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
@prefix owl: <http://www.w3.org/2002/07/owl#>.
@prefix xsd: <http://www.w3.org/2001/XMLSchema#>.
@prefix dce: <http://purl.org/dc/elements/1.1/>.
@prefix dct: <http://purl.org/dc/terms/>.
@prefix skos: <http://www.w3.org/2004/02/skos/core#>.
@prefix agent: <http://eulersharp.sourceforge.net/2003/03swap/agent#>.
@prefix event: <http://eulersharp.sourceforge.net/2003/03swap/event#>.
@prefix clineva: <http://www.agfa.com/w3c/2009/clinicalEvaluation#>.
@prefix clinproc: <http://www.agfa.com/w3c/2009/clinicalProcedure#>.
@prefix clinobs: <http://www.agfa.com/w3c/2009/clinicalObservation#>.
@prefix clisko: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>.
@prefix heca: <http://www.agfa.com/w3c/2009/healthCare#>.
@prefix humdis: <http://www.agfa.com/w3c/2009/humanDisorder#>.
@prefix ther: <http://www.agfa.com/w3c/2009/therapy#>.

<http://www.agfa.com/w3c/2009/therapy#>
	a owl:Ontology;
	dce:title """Therapy"""@en;
	dce:creator """Hans Cools, MD, Agfa Healthcare/Belgium"""@en;
	dce:contributor """Until 2010: Pieterjan De Potter, Pedro Debevere, Ghent University - IBBT/ELIS - Multimedia Lab/Belgium"""@en;
	dce:publisher """Agfa Healthcare/Belgium"""@en;
	dce:description """General description of clinical therapy."""@en;
	dce:format """OWL Full"""@en;
	rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group and Ghent University - IBBT/ELIS - Multimedia Lab. All Rights Reserved. THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group and Ghent University - IBBT/ELIS - Multimedia Lab The copyright notice above does not evidence any actual or intended publication of such source code."""@en.


#
# CLASSES
#

ther:Therapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """clinical therapy"""@en;
	skos:definition """An attempted remediation of a human health problem."""@en; # cf preventions in http://www.agfa.com/w3c/2009/clinicalProcedure#; different from therapy
	rdfs:subClassOf clinproc:Procedure, [
		a owl:Restriction; owl:onProperty event:hasInput; owl:someValuesFrom [owl:disjointUnionOf (clineva:Diagnosis clineva:AbsentDiagnosis)]], [
		a owl:Restriction; owl:onProperty event:after; owl:someValuesFrom clineva:Diagnosing];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "277132007"^^clisko:sct20080731DT].

ther:Monotherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """monotherapy"""@en;
	skos:definition """Applying 1 clinical therapy at a time."""@en;
	rdfs:subClassOf ther:Therapy.

ther:Polytherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """polytherapy"""@en;
	skos:definition """Applying 2 or more therapies simultaneously."""@en;
	rdfs:subClassOf ther:Therapy;
	skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "229554006"^^clisko:sct20080731DT].

ther:Intent
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """therapeutic intent"""@en;
	skos:definition """Intended effect of a clinical therapy on the evolution of a disorder."""@en;
	rdfs:subClassOf event:Intent;
	owl:oneOf (ther:Curative ther:Ameliorative ther:Stabilizing).

ther:Protocol
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:subClassOf clinproc:Pathway;
	skos:definition """Binding instructions for a therapy"""@en.

ther:Cycle
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """therapy cycle"""@en;
	skos:definition """Cycle as a clinical therapy that can be repeated."""@en;
	rdfs:comment """A clinical therapy can comprise a number of cycles. A cycle can comprise subprocedures, e.g. administrations of different drugs."""@en;
	rdfs:subClassOf ther:Therapy.

ther:Substance
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """therapeutic substance"""@en;
	skos:definition """Substance having a therapeutic effect."""@en;
	rdfs:subClassOf clinproc:Substance.

ther:TherapeuticRole
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """therapeutic role"""@en;
	skos:definition """Role of anything applied in a clinical therapy."""@en;
	rdfs:subClassOf agent:Role.

ther:TestedTherapeuticRole
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """tested therapeutic role"""@en;
	skos:definition """Therapeutic role confirmed in a test setting."""@en;
	rdfs:subClassOf ther:TherapeuticRole.

ther:CausalTherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """causal therapy"""@en;
	skos:definition """Therapy having effect on the cause of a disease."""@en;
	rdfs:subClassOf ther:Therapy;
	rdfs:subClassOf [a owl:Restriction; owl:onProperty event:hasInput; owl:someValuesFrom clineva:CertainDiagnosis].

ther:NonCausalTherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """noncausal therapy"""@en;
	skos:definition """Therapy having no effect on the cause of a disease."""@en;
	rdfs:subClassOf ther:Therapy.

ther:BlindTherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """blind therapy"""@en;
	skos:definition """Therapy started without knowing the cause of a disorder and/or the effect of a therapy."""@en;
	rdfs:subClassOf ther:Therapy #, rdfs:subClassOf [a owl:Restriction; owl:onProperty event:hasOutputLikelihood; owl:hasValue event:Unknown]
	.

ther:EmpiricalTherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """empirical therapy"""@en;
	skos:definition """Therapy started assuming possible effect based on experience (e.g. statistics) from similar cases."""@en;
	rdfs:subClassOf ther:Therapy;
	rdfs:subClassOf [a owl:Restriction; owl:onProperty event:hasOutputLikelihood; owl:hasValue event:Likely];
	skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "371018001"^^clisko:sct20080731DT].
	
ther:TargetedTherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """targeted therapy"""@en;
	skos:definition """Therapy wherein something is applied having a tested therapeutic role."""@en;
	rdfs:subClassOf ther:Therapy, [
		a owl:Restriction; owl:onProperty agent:hasAgent; owl:someValuesFrom [
			a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom ther:TestedTherapeuticRole]], [
		a owl:Restriction; owl:onProperty event:hasOutputLikelihood; owl:hasValue event:MostLikely].

ther:ExperimentalTherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """experimental therapy"""@en;
	skos:definition """Therapy wherein something is applied having an experimental therapeutic role."""@en;
	rdfs:subClassOf ther:Therapy, [a owl:Restriction; owl:onProperty event:hasState; owl:someValuesFrom event:Experimental].

#DrugTake rdfs:subClassOf x:SubstanceAbuse

ther:Device
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """therapy device"""@en;
	skos:definition """Device used in a clinical therapy."""@en;
	rdfs:subClassOf heca:Device.
	
ther:Drain
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """drain"""@en;
	rdfs:subClassOf ther:Device;
	skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "32712000"^^clisko:sct20080731DT].

ther:IntracerebralDrain	# to be replaced in dedicated ontology
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """intracerebral drain"""@en;
	rdfs:subClassOf ther:Drain;
	skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "258645009"^^clisko:sct20080731DT].

ther:EvacuationProcedure
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """evacuation procedure"""@en;
	rdfs:subClassOf ther:Therapy;
	skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "122461007"^^clisko:sct20080731DT].

ther:DrainageProcedure
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """drainage procedure"""@en;
	rdfs:subClassOf ther:EvacuationProcedure;
	skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "122462000"^^clisko:sct20080731DT].

ther:LumbarPunctureToLowerIntracranialPressure
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """lumbar puncture to lower intracranial pressure"""@en;
	rdfs:subClassOf ther:DrainageProcedure;
	skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "231062004"^^clisko:sct20080731DT].

ther:Surgery
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """clinical surgery"""@en;
	skos:definition """Clinical therapy involving opening the coverage (skin, cornea, mucosa, etc) of a human body."""@en;
	rdfs:subClassOf ther:Therapy;
	skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "387713003"^^clisko:sct20080731DT].

ther:OtherSurgeryThanSplenectomy
	skos:note """Just to show how far modelling can go :), created for a specific research project GUI."""@en;
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """other surgery than splenectomy"""@en;
	rdfs:subClassOf ther:Surgery.

ther:Response
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """clinical therapy response"""@en;
	skos:definition """Response of a human health disorder to a clinical therapy."""@en.

ther:Curative	#	with sequel OR restitutio ad integrum
	a rdfs:Class, ther:Intent;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """curative"""@en;
	skos:definition """Freeing of a health affliction."""@en.

ther:Ameliorative
	a rdfs:Class, ther:Intent;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """ameliorative"""@en;
	skos:definition """Lessening a health affliction."""@en.

ther:Stabilizing
	a rdfs:Class, ther:Intent;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """stabilizing"""@en;
	skos:definition """Stabilizing a health affliction."""@en.

# course of disease under therapy:
# curing
# ameliorating
# stabilizing
# worsening

ther:Residual
	a rdfs:Class, ther:Response;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """residual"""@en;
	skos:definition """State of a human health disorder remaining after therapy."""@en;
	rdfs:subClassOf humdis:Residual.

#
# PROPERTIES
#

ther:treatedWith
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical therapy wherewith a clinical finding is treated."""@en;
	#owl:propertyChainAxiom (clinobs:findingIn ther:treatedWith);
	rdfs:domain clinobs:Finding;
	rdfs:range ther:Therapy.

ther:maintainedWith
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical therapy wherewith a clinical finding is maintained."""@en;
	#owl:propertyChainAxiom (clinobs:findingIn ther:maintainedWith);
	rdfs:domain clinobs:Finding;
	rdfs:range ther:Therapy.	

ther:firstTreatedWith
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """first treated with"""@en;
	skos:definition """Specifying a primary clinical therapy wherewith a clinical finding is treated."""@en;
	skos:note """Used in an N3 rule to establish this relation."""@en;
	#owl:propertyChainAxiom (clinobs:findingIn ther:treatedWith);
	rdfs:domain clinobs:Finding;
	rdfs:range ther:Therapy.

ther:secondarilyTreatedWith
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	rdfs:label """secondarily treated with"""@en;
	skos:definition """Specifying a secondary clinical therapy wherewith a clinical finding is treated."""@en;
	skos:note """Used in an N3 rule to establish this relation."""@en;
	#owl:propertyChainAxiom (clinobs:findingIn ther:treatedWith);
	rdfs:domain clinobs:Finding;
	rdfs:range ther:Therapy.

ther:notTreatedWith
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical therapy not used for treating a clinical finding."""@en;
	rdfs:domain clinobs:Finding;
	rdfs:range ther:Therapy.

ther:usedToTreat
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical finding treated with a clinical therapy."""@en;
	rdfs:domain ther:Therapy;
	rdfs:range clinobs:Finding.

ther:treatedBy
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a health care professional treating a patient."""@en;
	rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Patient];
	rdfs:range [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Professional].

ther:treats # who, that treats
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a patient treated by a health care professional."""@en;
	owl:inverseOf ther:treatedBy;
	rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Professional];
	rdfs:range [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Patient].

ther:treatedIn
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a therapy wherein a patient is treated."""@en;
	rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Patient];
	rdfs:range ther:Therapy.

ther:whereinTreated
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a patient treated in a therapy."""@en;
	owl:inverseOf ther:treatedIn;
	rdfs:domain ther:Therapy;
	rdfs:range [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Patient].

ther:hasIntent
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a therapeutic intent of a clinical therapy."""@en;
	rdfs:subPropertyOf event:hasIntent;
	rdfs:domain ther:Therapy;
	rdfs:range ther:Intent.

ther:hasNumberOfCycles
	a owl:DatatypeProperty, owl:FunctionalProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a number of cycles of a clinical therapy."""@en;
	#owl:propertyChainAxiom (ther:hasCycle quant:hasNumber quant:hasMeasurement quant:hasValue);
	rdfs:domain ther:Therapy;
	rdfs:range xsd:decimal.

ther:hasTherapyResponse
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a response of a human health disorder to a clinical therapy."""@en;
	owl:propertyChainAxiom (ther:treatedWith ther:wheretoResponse);
	rdfs:domain humdis:Disorder;
	rdfs:range humdis:State.

ther:therapyResponseOf
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a human health disorder having a response to a clinical therapy."""@en;
	owl:propertyChainAxiom (ther:responseTo ther:usedToTreat);
	rdfs:domain humdis:State;
	rdfs:range humdis:Disorder.

ther:responseTo
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical therapy whereto of a human health disorder has a response."""@en;
	rdfs:subPropertyOf event:outputOf;
	owl:propertyChainAxiom (humdis:stateOf ther:treatedWith);
	rdfs:domain humdis:State;
	rdfs:range ther:Therapy.

ther:wheretoResponse
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a response of a human health disorder to a clinical therapy."""@en;
	rdfs:subPropertyOf event:hasOutput;
	owl:propertyChainAxiom (ther:usedToTreat humdis:hasState);
	rdfs:domain ther:Therapy;
	rdfs:range humdis:State.

ther:hasResponseTo
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical therapy a human health disorder has a response to."""@en;
	owl:propertyChainAxiom (ther:hasTherapyResponse ther:responseTo);
	rdfs:domain humdis:Disorder;
	rdfs:range ther:Therapy.

ther:hasCompleteRemissionAfter
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical therapy whereafter a human health disorder has a complete remission."""@en;
	rdfs:subPropertyOf ther:hasResponseTo;
	rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:CompleteRemission];
	rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:CompleteRemission].

ther:hasCompleteRemissionIPNAfter
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical therapy whereafter a human health disorder has a complete remission with insufficient platelets or neutrophils recovery."""@en;
	rdfs:subPropertyOf ther:hasResponseTo;
	rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:CompleteRemissionIPN];
	rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:CompleteRemissionIPN].

ther:hasCompleteRemissionUnconfirmedAfter
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical therapy whereafter a human health disorder has an unconfirmed complete remission."""@en;
	rdfs:subPropertyOf ther:hasResponseTo;
	rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:CompleteRemissionUnconfirmed];
	rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:CompleteRemissionUnconfirmed].

ther:hasPartialRemissionAfter
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical therapy whereafter a human health disorder has a partial remission."""@en;
	rdfs:subPropertyOf ther:hasResponseTo;
	rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:PartialRemission];
	rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:PartialRemission].

ther:hasNodularPartialRemissionAfter
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical therapy whereafter a human health disorder has a nodular partial remission."""@en;
	rdfs:subPropertyOf ther:hasResponseTo;
	rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:NodularPartialRemission];
	rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:NodularPartialRemission].

ther:stableAfter
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical therapy whereafter a human health disorder is stable."""@en;
	rdfs:subPropertyOf ther:hasResponseTo;
	rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:Stable];
	rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:Stable].

ther:progressiveAfter
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a clinical therapy whereafter a human health disorder is progressive."""@en;
	rdfs:subPropertyOf ther:hasResponseTo;
	rdfs:domain [a owl:Restriction; owl:onProperty ther:hasTherapyResponse; owl:someValuesFrom humdis:Progressive];
	rdfs:range [a owl:Restriction; owl:onProperty ther:wheretoResponse; owl:someValuesFrom humdis:Progressive].

ther:replaces
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a therapy replaced by another for the same patient and disease."""@en;
	skos:note """further formalization in an N3 rule."""@en;
	rdfs:domain ther:Therapy;
	rdfs:range ther:Therapy.

ther:addedTo
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/therapy#>;
	skos:definition """Specifying a therapy to which another is added for the same patient and disease."""@en;
	skos:note """further formalization in an N3 rule."""@en;
	rdfs:domain ther:Therapy;
	rdfs:range ther:Therapy.