@prefix dce: <http://purl.org/dc/elements/1.1/>.
@prefix owl: <http://www.w3.org/2002/07/owl#>.
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
@prefix skos: <http://www.w3.org/2004/02/skos/core#>.
@prefix event: <http://eulersharp.sourceforge.net/2003/03swap/event#>.
@prefix clisko: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>.
@prefix quant: <http://eulersharp.sourceforge.net/2003/03swap/quantities#>.
@prefix units: <http://eulersharp.sourceforge.net/2003/03swap/units#>.
@prefix human: <http://eulersharp.sourceforge.net/2003/03swap/human#>.
@prefix clinlabproc: <http://www.agfa.com/w3c/2009/clinicalLabProcedure#>.
@prefix refuex: <http://www.agfa.com/w3c/2009/renalFunctionExamination#>.

<http://www.agfa.com/w3c/2009/renalFunctionExamination>
	a owl:Ontology;
	dce:title """Renal Function Examination"""@en;
	dce:creator """Hans Cools, MD, Agfa Healthcare/Belgium"""@en;
	dce:publisher """Agfa Healthcare/Belgium"""@en;
	dce:description """Formal general description of renal function examination."""@en;
	dce:source <http://www.urology-textbook.com/kidney-glomerular-filtration-rate.html>;
	dce:format """OWL Full"""@en;
	rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group. All Rights Reserved. THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group. The copyright notice above does not evidence any actual or intended publication of such source code."""@en.

#
# CLASSES
#

refuex:CreatinineSerumConcentration
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/renalFunctionExamination#>;
	rdfs:label """creatinine serum concentration"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf quant:MassConcentration.

refuex:CreatinineSerumConcentrationMeasurement
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/renalFunctionExamination#>;
	rdfs:label """creatinine serum concentration measurement"""@en;
	skos:definition """."""@en;
	rdfs:subClassOf clinlabproc:Examination, quant:MassConcentrationMeasurement, [
		a owl:Restriction; owl:onProperty quant:measurementOf; owl:someValuesFrom refuex:CreatinineSerumConcentration], [
		a owl:Restriction; owl:onProperty quant:hasUnit; owl:someValuesFrom [
			a owl:Restriction; owl:onProperty quant:unitOf; owl:someValuesFrom quant:MassConcentrationMeasurement]];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "113075003"^^clisko:sct20080731DT].

refuex:CreatinineClearanceRate
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/renalFunctionExamination#>;
	rdfs:label """creatinine clearance rate"""@en;
	skos:definition """Volume of blood plasma cleared of creatinine, i.e. passing through the surface of the kidneys' filters, per unit of time."""@en;
	rdfs:comment """Estimation of glomerular filtration rate."""@en;
	rdfs:subClassOf quant:VolumeFLowRate.

refuex:CreatinineClearanceRateMeasurement
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/renalFunctionExamination#>;
	rdfs:label """creatinine clearance rate measurement"""@en;
	rdfs:comment """E.g. estimated with http://eulersharp.sourceforge.net/2003/03swap/cockroftGaultCalculation#;
	using modified formula of Cockroft and Gault: Cl_crea = (140-age) x BW / F x S_crea;
	Cl_crea: creatinine clearance rate estimation in ml/min;
	age value in years;
	BW: body weight value in kg;
	F: gender factor, female: 85, male: 72;
	S_crea: creatinine serum concentration measurement value in mg/dl."""@en;
	rdfs:subClassOf clinlabproc:Examination, quant:VolumeFLowRateMeasurement, [
		a owl:Restriction; owl:onProperty quant:measurementOf; owl:someValuesFrom refuex:CreatinineClearanceRate], [
		a owl:Restriction; owl:onProperty quant:hasUnit; owl:someValuesFrom units:milliliterPerMinute], [
		a owl:Restriction; owl:onProperty quant:hasFactor; owl:someValuesFrom refuex:GenderFactor].

refuex:GenderFactor
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/renalFunctionExamination#>;
	rdfs:label """creatinine clearance rate estimation gender factor"""@en;
	skos:definition """Factor for a gender in modified formula of Cockroft and Gault to estimate a creatinine clearance rate."""@en;
	rdfs:subClassOf quant:Factor;
	owl:oneOf (85 72).

#
# PROPERTES
#

refuex:hasGenderFactor
	a owl:DatatypeProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/renalFunctionExamination#>;
	skos:definition """Specifying creatinine clearance rate measurement gender factor of a person."""@en;
	rdfs:domain human:Person;
	rdfs:range refuex:GenderFactor.