@prefix owl: <http://www.w3.org/2002/07/owl#>.
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
@prefix xsd: <http://www.w3.org/2001/XMLSchema#>.
@prefix dce: <http://purl.org/dc/elements/1.1/>.
@prefix skos: <http://www.w3.org/2004/02/skos/core#>.
@prefix fma: <http://purl.org/sig/fma/>.
@prefix event: <http://eulersharp.sourceforge.net/2003/03swap/event#>.
@prefix ana: <http://www.agfa.com/w3c/2009/anatomy#>.
@prefix clinobs: <http://www.agfa.com/w3c/2009/clinicalObservation#>.
@prefix clisko: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>.
@prefix agent: <http://eulersharp.sourceforge.net/2003/03swap/agent#>.
@prefix human: <http://eulersharp.sourceforge.net/2003/03swap/human#>.
@prefix heca: <http://www.agfa.com/w3c/2009/healthCare#>.
@prefix clinmorph: <http://www.agfa.com/w3c/2009/clinicalMorphology#>.
@prefix humdis: <http://www.agfa.com/w3c/2009/humanDisorder#>.

<http://www.agfa.com/w3c/2009/humanDisorder#>
	a owl:Ontology;
	dce:title """Human Disorder"""@en;
	dce:creator """Hans Cools, MD; Agfa Healthcare/Belgium"""@en;
	dce:contributor """Until 2010: Pieterjan De Potter; Ghent University - IBBT/ELIS - Multimedia Lab/Belgium"""@en;
	dce:publisher """Agfa Healthcare/Belgium"""@en;
	dce:description """Formal description of human health disorder."""@en;
	dce:format """OWL Full"""@en;
	rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group / Ghent University - IBBT/ELIS - Multimedia Lab All Rights Reserved THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group/ Ghent University - IBBT/ELIS - Multimedia Lab The copyright notice above does not evidence any actual or intended publication of such source code."""@en.

#
# CLASSES
#

humdis:Disorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """human health disorder"""@en;
	skos:definition """Disturbance of a healthy functioning of a human."""@en;
	rdfs:subClassOf clinobs:Finding, event:AdverseProcess, event:Action;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "64572001"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icpc2; skos:notation "A99"^^clisko:icpc2DT].

humdis:Comorbidity
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """comorbidity"""@en;
	skos:definition """Human health disorder simultaneously but independently with another one."""@en;
	rdfs:subClassOf humdis:Disorder;
	skos:note """E.g. hypertension is a common comorbidity of diabetes."""@en.

humdis:State
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """human health disorder state"""@en;
	skos:definition """Mode of being of a human health disorder."""@en;
	rdfs:subClassOf event:State.

humdis:Injury
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """injury"""@en;
	rdfs:subClassOf humdis:Disorder.

humdis:GeneticDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """genetic disorder"""@en;
	skos:definition """Human health disorder caused by a genome abnormality."""@en;
	rdfs:subClassOf humdis:Disorder.

humdis:Neoplasia
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """neoplasia"""@en;
	skos:definition """Abnormal cell proliferation."""@en;
	rdfs:subClassOf humdis:Disorder, [
		a owl:Restriction; owl:onProperty event:hasOutput; owl:someValuesFrom clinmorph:Neoplasm].

humdis:ImmuneSystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """immune system disorder"""@en;
	rdfs:subClassOf humdis:Disorder.

humdis:AutoimmuneDisorder # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """autoimmune disorder"""@en;
	skos:definition """Overactive immune response of the human body against sui generis substances."""@en;
	rdfs:subClassOf humdis:ImmuneSystemDisorder.

humdis:NervousSystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """nervous system disorder"""@en;
	rdfs:subClassOf humdis:Disorder.

humdis:CirculatorySystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """circulatory system disorder"""@en;
	rdfs:subClassOf humdis:Disorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "49601007"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icpc2; skos:notation "K99"^^clisko:icpc2DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "I99"^^clisko:icd10DT].

humdis:DigestiveSystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """digestive system disorder"""@en;
	rdfs:subClassOf humdis:Disorder.

humdis:RespiratorySystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """respiratory system disorder"""@en;
	rdfs:subClassOf humdis:Disorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "50043002"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icpc2; skos:notation "R99"^^clisko:icpc2DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "J98.9"^^clisko:icd10DT].

humdis:GenitourinarySystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """disorder of the genuitourinary system"""@en;
	rdfs:subClassOf humdis:Disorder, [
		a owl:Restriction; owl:onProperty clinobs:hasSite; owl:allValuesFrom ana:GenitourinarySystemStructure];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "42030000"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "N99.9"^^clisko:icd10DT].

humdis:EndocrineSystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """endocrine system disorder"""@en;
	rdfs:subClassOf humdis:Disorder.

humdis:Obesity
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """obesity"""@en;
	skos:definition """Human health disorder caused by having too much fat tissue."""@en;
	rdfs:subClassOf humdis:Disorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "414916001"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "E66"^^clisko:icd10DT].

humdis:CerebroVascularDisorder  # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """cerebrovascular disorder"""@en;
	rdfs:subClassOf humdis:CirculatorySystemDisorder.

humdis:CerebralInfarction  # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """cerebral infarction"""@en;
	rdfs:subClassOf humdis:CerebroVascularDisorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "I63"^^clisko:icd10DT].

humdis:Stroke  # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """stroke"""@en;
	rdfs:subClassOf humdis:CerebroVascularDisorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:icpc2; skos:notation "K90"^^clisko:icpc2DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "I64"^^clisko:icd10DT].

humdis:UpperRespiratoryTractDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """upper repiratory tract disorder"""@en;
	rdfs:subClassOf humdis:RespiratorySystemDisorder.

humdis:AcuteMaxillarySinusitis  # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """acute maxillary sinusitis"""@en;
	rdfs:subClassOf humdis:UpperRespiratoryTractDisorder;
	skos:closeMatch [
		a skos:Concept; skos:inScheme clisko:icpc2; skos:notation "R75"^^clisko:icpc2DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "J01.0"^^clisko:icd10DT].

humdis:LowerRespiratoryTractDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """disorder of the lower repiratory system"""@en;
	rdfs:subClassOf humdis:RespiratorySystemDisorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "128272009"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icpc2; skos:notation "R99"^^clisko:icpc2DT].

humdis:LungDisorder   # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """lung disorder"""@en;
	rdfs:subClassOf humdis:LowerRespiratoryTractDisorder.
	# clinobs:hasSite fma Lung

humdis:Pneumonia # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """pneumonia"""@en;
	skos:definition """Inflammation of any part of the lung parenchyma."""@en;
	rdfs:subClassOf humdis:LungDisorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "205237003"^^clisko:sct20080731DT].

humdis:Asthma   # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """asthma"""@en;
	rdfs:subClassOf humdis:LowerRespiratoryTractDisorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "J45"^^clisko:icd10DT].

humdis:AllergicAsthma   # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """allergic asthma"""@en;
	rdfs:subClassOf humdis:Asthma;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "J45.0"^^clisko:icd10DT].

humdis:NonallergicAsthma   # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """nonallergic asthma"""@en;
	rdfs:subClassOf humdis:Asthma;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:icpc2; skos:notation "R96"^^clisko:icpc2DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "J45.1"^^clisko:icd10DT].

humdis:ChronicObstructivePulmonaryDisease   # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """chronic obstructive pulmonary disease"""@en;
	rdfs:subClassOf humdis:LungDisorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "J44"^^clisko:icd10DT].

humdis:LiverDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """liver disorder"""@en;
	rdfs:subClassOf humdis:DigestiveSystemDisorder.

humdis:AlcoholicLiverDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """liver disorder"""@en;
	rdfs:subClassOf humdis:LiverDisorder, [
	a skos:Concept; skos:inScheme clisko:icd10; skos:notation "K70"^^clisko:icd10DT].

humdis:AlcoholicFattyLiver
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """alcoholic fatty liver"""@en;
	rdfs:subClassOf humdis:AlcoholicLiverDisorder, [
	a skos:Concept; skos:inScheme clisko:icd10; skos:notation "K70.0"^^clisko:icd10DT].

humdis:AlcoholicLiverCirrhosis
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """alcoholic liver cirrhosis"""@en;
	rdfs:subClassOf humdis:AlcoholicLiverDisorder, [
	a skos:Concept; skos:inScheme clisko:icd10; skos:notation "K70.3"^^clisko:icd10DT].

humdis:NonalcoholicLiverCirrhosis
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """nonalcoholic liver cirrhosis"""@en;
	rdfs:subClassOf humdis:LiverDisorder, [
	a skos:Concept; skos:inScheme clisko:icd10; skos:notation "K74.6"^^clisko:icd10DT].

humdis:UrinarySystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """disorder of the urinary system"""@en;
	rdfs:subClassOf humdis:GenitourinarySystemDisorder, [
		a owl:Restriction; owl:onProperty clinobs:hasSite; owl:allValuesFrom ana:UrinarySystemStructure];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "128606002"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icpc2; skos:notation "U99"^^clisko:icpc2DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "N39.9"^^clisko:icd10DT].

humdis:UpperUrinaryTractDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """disorder of the upper urinary tract"""@en;
	rdfs:subClassOf humdis:UrinarySystemDisorder.

humdis:LowerUrinaryTractDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """disorder of the lower urinary tract"""@en;
	rdfs:subClassOf humdis:UrinarySystemDisorder;
	rdfs:subClassOf [
		a owl:Restriction; owl:onProperty clinobs:hasSite; owl:allValuesFrom ana:LowerUrinaryTractStructure];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "7793005"^^clisko:sct20080731DT].

humdis:Cystitis   # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """cystitis"""@en;
	skos:definition """Inflammation of the urinary bladder."""@en;
	rdfs:subClassOf humdis:LowerUrinaryTractDisorder;
	rdfs:subClassOf [
		a owl:Restriction; owl:onProperty clinobs:hasSite; owl:allValuesFrom fma:Urinary_bladder].

humdis:CentralNervousSystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """central nervous system disorder"""@en;
	rdfs:subClassOf humdis:NervousSystemDisorder.

humdis:MusculoskeletalDisorder
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """musculoskeletal disorder"""@en;
	rdfs:subClassOf humdis:Disorder.

humdis:Sciatica   # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:subClassOf humdis:MusculoskeletalDisorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:icpc2; skos:notation "L86"^^clisko:icpc2DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "M54.3"^^clisko:icd10DT].

humdis:Hypercholesterolaemia
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """hypercholesterolaemia"""@en;
	rdfs:subClassOf humdis:Disorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "13644009"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "E78.0"^^clisko:icd10DT].

humdis:Hyperlipidemia
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """hyperlipidemia"""@en;
	rdfs:subClassOf humdis:Disorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "55822004"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "E78.5"^^clisko:icd10DT].

humdis:Idiopathic
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """idiopathic"""@en;
	skos:definition """State of a human health disorder having no known cause."""@en.

humdis:Secondary
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """secondary"""@en;
	skos:definition """State of a human health disorder being secondary to another one in certain circumstances."""@en;
	skos:note """Does not mean that the second is necessarily directly caused by the first; e.g. a secondary malignant neoplasia caused by chemotherapy for a primary malignant neoplasia; secondary bacterial pharyngeal infection after viral infection damaging the mucosa; seondary Candida albicans infection after antibiotic therapy for bacterial infection."""@en.

humdis:Acute
	a rdfs:Class, humdis:State, event:OnsetMode, event:CourseMode;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """acute"""@en;
	skos:definition """State of a human health disorder having a rapid onset and progression, following a short course."""@en;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "373933003"^^clisko:sct20080731DT].

humdis:Invasive
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """invasive"""@en;
	skos:definition """State of a human health disorder crossing tissue border."""@en;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "10179008"^^clisko:sct20080731DT].

humdis:Metastasic
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """metastasic"""@en;
	skos:definition """State of a human health disorder spreading discontinuously."""@en.

humdis:Malignant
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """malignant"""@en;
	skos:definition """State of a human health disorder being severe and progressively worsening, potentially resulting in death."""@en.

humdis:Benign
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """benign"""@en;
	skos:definition """State of a human health disorder being not severe and not progressively worsening."""@en.

humdis:Monoclonal
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """monoclonal"""@en;
	skos:definition """State of a human health disorder having a massive expansion of a single B-cell clone."""@en.

humdis:Transformed
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """transformed"""@en;
	skos:definition """State of a human health disorder being transformed from another disorder."""@en.

humdis:Untransformed
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """untransformed"""@en;
	skos:definition """State of a human health disorder being not transformed from another disorder."""@en.

humdis:CompleteRemission # cured, restitutio ad integrum ?
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """complete remission"""@en;
	skos:definition """State of complete remission of a human health disorder, not detectable anymore."""@en;
	skos:note """Not necessarily after therapy."""@en;
	rdfs:comment """The NCI definition is narrower: disappearance of all signs of cancer in response to treatment, which does not always mean the cancer has been cured."""@en;
	skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "103338009"^^clisko:sct20080731DT].
	
humdis:CompleteRemissionIPN
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """complete remission with insufficient platelets or neutrophils recovery"""@en;
	skos:definition """State of complete remission of a human health disorder with insufficient platelets or neutrophils recovery."""@en.

humdis:CompleteRemissionUnconfirmed
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """complete remission unconfirmed"""@en;
	skos:definition """State of complete remission of a human health disorder, unconfirmed."""@en.

humdis:PartialRemission
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """partial remission"""@en;
	skos:definition """State of partial remission of a human health disorder."""@en;
	skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "103337004"^^clisko:sct20080731DT].

humdis:NodularPartialRemission
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """nodular partial remission"""@en;
	skos:definition """State of partial remission with persistent lymphoid nodules in the bone marrow (NCI)."""@en.

humdis:Stable
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """stable"""@en;
	skos:definition """State of a human health disorder being stable."""@en.

humdis:Progressive
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """progressive"""@en;
	skos:definition """State of a human health disorder being progressive."""@en.

humdis:Residual
	a rdfs:Class, humdis:State;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	rdfs:label """residual"""@en;
	skos:definition """State of a human health disorder being residual."""@en.

#
# PROPERTIES
#

humdis:hasState
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a state of a human health disorder."""@en;
	rdfs:domain humdis:Disorder;
	rdfs:range humdis:State.

humdis:hasNotState
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a state a human health disorder has not."""@en;
	rdfs:comment """Ruled out through examination and evaluation."""@en;
	rdfs:domain humdis:Disorder;
	rdfs:range humdis:State.

humdis:stateOf
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a human health disorder having a state."""@en;
	owl:inverseOf humdis:hasState;
	rdfs:domain humdis:State;
	rdfs:range humdis:Disorder.

humdis:isNotState
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a state a human health disorder state is not."""@en;
	rdfs:comment """Ruled out through examination and evaluation."""@en;
	rdfs:domain humdis:State;
	rdfs:range humdis:State.

humdis:hasDisorder
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a health disorder a human has."""@en;
	rdfs:subPropertyOf agent:actsIn;
	rdfs:domain human:Human;
	rdfs:range humdis:Disorder.

humdis:disorderIn
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a human having a health disorder."""@en;
	rdfs:subPropertyOf agent:hasAgent;
	owl:inverseOf humdis:hasDisorder;
	rdfs:domain humdis:Disorder;
	rdfs:range human:Human.

humdis:isNotDisorder
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a health disorder a human health disorder is not."""@en;
	rdfs:comment """Ruled out through examination and evaluation."""@en;
	rdfs:domain humdis:Disorder;
	rdfs:range humdis:Disorder.

humdis:hasComorbidity
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a health disorder as comorbidity of another health disorder."""@en;
	rdfs:domain humdis:Disorder;
	rdfs:range humdis:Comorbidity.

humdis:comorbidityOf
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a health disorder as comorbidity of another health disorder."""@en;
	owl:inverseOf humdis:hasComorbidity;
	rdfs:domain humdis:Comorbidity;
	rdfs:range humdis:Disorder.

humdis:curedFrom
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a disorder a patient cured from."""@en;
	rdfs:domain human:Human;
	rdfs:range humdis:Disorder.

humdis:transformsIn
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a human health disorder being a transformation of another human health disorder."""@en;
	skos:note """E.g. chronic lymphocytic leukemia transforms into diffuse large B-cell lymphoma (in Richter syndrome)."""@en;
#	rdfs:subPropertyOf event:evolvesTo;
	rdfs:domain humdis:Disorder;
	rdfs:range humdis:Disorder.

humdis:isTransformationOf
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a human health disorder transformed into another human health disorder."""@en;
	skos:note """E.g. diffuse large B-cell lymphoma is transformation of chronic lymphocytic leukamia (in Richter syndrome)."""@en;
#	rdfs:subPropertyOf event:evolvesFrom;
	rdfs:domain humdis:Disorder;
	rdfs:range humdis:Disorder.

humdis:hasTransformationOf
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a human health disorder transformed during another human health disorder."""@en;
	skos:note """E.g. Richter syndrome has transformation of chronic lymphocytic leukamia (into diffuse large B-cell lymphoma)."""@en;
	rdfs:domain humdis:Disorder;
	rdfs:range humdis:Disorder.

humdis:hasTransformation
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a human health disorder being a transformation during another human health disorder."""@en;
	skos:note """E.g. Richter syndrome has transformation diffuse large B-cell lymphoma (of chronic lymphocytic leukamia)."""@en;
	rdfs:domain humdis:Disorder;
	rdfs:range humdis:Disorder.

humdis:hasComplication
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a complication of a human health disorder."""@en;
#	rdfs:subPropertyOf event:evolvesTo;
	rdfs:domain humdis:Disorder;
	rdfs:range humdis:Disorder.

humdis:complicationOf
	a owl:ObjectProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying a human health disorder having a complication."""@en;
#	rdfs:subPropertyOf event:evolvesFrom;
	rdfs:domain humdis:Disorder;
	rdfs:range humdis:Disorder.

humdis:hasIncubationPeriod
	a owl:DatatypeProperty, owl:FunctionalProperty;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/humanDisorder#>;
	skos:definition """Specifying for a human disorder a period from exposure of a human to an agent and observation of the disorder the agent causes."""@en;
	rdfs:domain humdis:Disorder;
	rdfs:range xsd:Duration.