@prefix rdf: . @prefix rdfs: . @prefix owl: . @prefix xsd: . @prefix dce: . @prefix skos: . @prefix foaf: . @prefix unit: . @prefix mrela: . @prefix screla: . @prefix agent: . @prefix event: . @prefix physical: . @prefix space: . @prefix humanbody: . @prefix quant: . @prefix units: . @prefix clineva: . @prefix clinproc: . @prefix clisko: . @prefix hurifa: . @prefix ther: . @prefix heca: . @prefix clinobs: . @prefix dradfo: . @prefix drug: . a owl:Ontology; dce:title """Drug Therapy"""@en; dce:creator """Hans Cools, MD; Agfa Healthcare/Belgium"""@en; dce:contributor """Until 2010: Pieterjan De Potter; Ghent University - IBBT/ELIS - Multimedia Lab/Belgium"""@en; dce:publisher """Agfa Healthcare/Belgium"""@en; dce:description """Formal general description of clinical drug therapy."""@en; dce:format """OWL-Full"""@en; rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group and Ghent University - IBBT/ELIS - Multimedia Lab. All Rights Reserved. THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group and Ghent University - IBBT/ELIS - Multimedia Lab The copyright notice above does not evidence any actual or intended publication of such source code."""@en. # # CLASSES # drug:Therapy a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug therapy"""@en; skos:definition """Clinical therapy implying administration of a drug."""@en; rdfs:subClassOf ther:Therapy, [ a owl:Restriction; owl:onProperty event:hasSubProcedure; owl:someValuesFrom drug:Administering]; skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "416608005"^^clisko:sct20080731DT]. drug:Administering a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug administering"""@en; skos:definition """Administering a clinical drug to a patient."""@en; rdfs:subClassOf clinproc:SubstanceAdministering, [ a owl:Restriction; owl:onProperty event:hasObject; owl:someValuesFrom drug:AdministrationForm], [ a owl:Restriction; owl:onProperty quant:hasFrequency; owl:someValuesFrom drug:AdministeringFrequency], [ a owl:Restriction; owl:onProperty clinproc:whereinAdministered; owl:someValuesFrom drug:AdministrationForm], [ a owl:Restriction; owl:onProperty event:hasOutput; owl:someValuesFrom drug:Administration]; skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "18629005"^^clisko:sct20080731DT]. drug:Administration a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug administration"""@en; skos:definition """Output of clinical drug administering."""@en; rdfs:subClassOf [ a owl:Restriction; owl:onProperty event:outputOf; owl:someValuesFrom drug:Administering], [ a owl:Restriction; owl:onProperty clinproc:administrationOf; owl:someValuesFrom drug:AdministrationForm]. drug:Substance a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug substance"""@en; skos:definition """Substance, when absorbed into a patient's body, aims at restoring a function or preventing a deterioration."""@en; rdfs:subClassOf clinproc:Substance, agent:DrugSubstance, [ a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom drug:Role]; skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "410942007"^^clisko:sct20080731DT]. drug:Role # -> DUO? a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug role"""@en; skos:definition """Role of a clinical drug substance."""@en; rdfs:subClassOf ther:TherapeuticRole, clinproc:PreventiveRole, clineva:DiagnosticRole, [ a owl:Restriction; owl:onProperty agent:rolePlayedBy; owl:someValuesFrom drug:Substance]. drug:ExperimentalSubstance a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """experimental clinical drug"""@en; skos:definition """Substance used as drug in an experimental clinical setting."""@en; rdfs:subClassOf drug:Substance; skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "902003"^^clisko:sct20080731DT]. drug:Concentration a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug strength"""@en; skos:definition """Concentration of a clinical drug as active substance in an administration form."""@en; rdfs:subClassOf quant:Concentration. # drug:ConcentrationMeasurement drug:Product a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug product"""@en; skos:definition """Clinical drug as suitable for administration."""@en; rdfs:comment """Clinical drug usually produced by a pharmaceutical company."""@en; skos:note """A placebo does not contain a known active part."""@en; rdfs:subClassOf physical:Product, physical:Compound, [ a owl:Restriction; owl:onProperty space:containedBy; owl:someValuesFrom drug:AdministrationForm]. drug:Excipient a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug product excipient"""@en; skos:definition """Substance added to a clinical drug product, having an effect other than a clinical drug substance; cf http://www.agfa.com/w3c/2009/drugExcipients#."""@en; skos:note """cf http://www.agfa.com/w3c/2009/drugExcipients#."""@en; rdfs:subClassOf clinproc:Substance. drug:ExcipientRole a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug product excipient role"""@en; skos:definition """Role of a clinical drug product excipient."""@en; rdfs:subClassOf agent:Role. drug:Compound a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug compound"""@en; skos:definition """Clinical drug product containing more than 1 active substance."""@en; rdfs:subClassOf drug:Product, [ a owl:Restriction; owl:onProperty drug:hasActivePart; owl:minCardinality "2"^^xsd:nonNegativeInteger]. drug:AdministrationForm a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug administration form"""@en; skos:definition """Form in which a clinical drug product is administered."""@en; rdfs:subClassOf physical:Product, clinproc:AdministrableSubstance, [ a owl:Restriction; owl:onProperty space:contains; owl:someValuesFrom drug:Product]; skos:exactMatch [ a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "421967003"^^clisko:sct20080731DT]. # drug:dose, eg. nasal spray # unit dose, e.g. puff, ampoule # skos:exactMatch [ # a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "408102007"^^clisko:sct20080731DT]. drug:Package a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug package"""@en; skos:definition """Clinical drug as available for purchase."""@en; rdfs:subClassOf physical:Product, [ a owl:Restriction; owl:onProperty space:contains; owl:someValuesFrom drug:PackageUnit]. drug:CombiPackage a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug combination package"""@en; skos:definition """Clinical drug package containing more than 1 administration form, each in its own package."""@en; rdfs:subClassOf physical:Product, [ a owl:Restriction; owl:onProperty space:contains; owl:someValuesFrom drug:Package], [ a owl:Restriction; owl:onProperty space:contains; owl:minCardinality "2"^^xsd:nonNegativeInteger]. drug:PackageUnit a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug package unit"""@en; skos:definition """Individually packaged clinical drug administration form unit."""@en; rdfs:comment """E.g. tablet, ampoule, infusion bag, bottle."""@en; rdfs:subClassOf physical:Product, [ a owl:Restriction; owl:onProperty space:contains; owl:someValuesFrom drug:AdministrationForm]. drug:PackageUnitQuantity a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug package unit quantity"""@en; skos:definition """Quantity in which a clinical drug administration form is available."""@en; rdfs:comment """E.g. an injection solution available in 3 milliliter."""@en; rdfs:subClassOf [owl:disjointUnionOf (quant:Mass quant:Volume drug:AdministrationFormQuantity)]. drug:Monotherapy a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """monodrug therapy"""@en; skos:definition """Clinical therapy implying administration of 1 drug at a time."""@en; rdfs:subClassOf drug:Therapy. drug:Polytherapy a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """polydrug therapy"""@en; skos:definition """Clinical therapy implying administration of 2 or more drugs simultaneously."""@en; rdfs:subClassOf drug:Therapy. drug:Dosage a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug dosage"""@en; skos:definition """Clinical drug administration form dosed in a quantity, as output of clinical drug dosing, given at one time."""@en; rdfs:comment """E.g. 3 (x 1) tablets, 3 x 5 ml sirup (= 3 tsp sirup)."""@en. drug:DosageQuantity a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug administration form dosage quantity"""@en; skos:definition """Quantity in which a clinical drug administration form is dosed."""@en; rdfs:comment """E.g. 3 (x 1) tablets, 3 x 5 ml (= 3 tsp) (sirup)."""@en; rdfs:subClassOf [owl:disjointUnionOf (quant:Mass quant:Volume drug:AdministrationFormQuantity)]. drug:AdministrationFormQuantity a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug administration form quantity"""@en; skos:definition """Quantity of a drug administration form of which the unit is the drug administration form itself."""@en; rdfs:comment """E.g. 3 tablets."""@en; rdfs:subClassOf quant:PhysicalQuantity, [ a owl:Restriction; owl:onProperty quant:hasMeasurement; owl:allValuesFrom [ a owl:Restriction; owl:onProperty quant:hasUnit; owl:someValuesFrom drug:administrationFormUnit]]. drug:AdministeringFrequency a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug administering frequency"""@en; skos:definition """Frequency of clinical drug administering."""@en; rdfs:subClassOf quant:Frequency, [ a owl:Restriction; owl:onProperty quant:frequencyOf; owl:someValuesFrom drug:Administering]. drug:Prescribing a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug prescribing"""@en; skos:definition """Clinical prescribing, describing one or more drugs and how to administer them."""@en; rdfs:subClassOf clinproc:Prescribing, [ a owl:Restriction; owl:onProperty event:hasOutput; owl:allValuesFrom drug:Prescription]. drug:Prescription a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug prescription"""@en; skos:definition """Clinical prescription as outcome of clinical drug prescribing."""@en; rdfs:comment """E.g. R/ Glucophage 500 mg; DT/ 1 package 60 tablets; S/ 3 x 1 tablet/day."""@en; rdfs:subClassOf clinproc:Prescription, [ a owl:Restriction; owl:onProperty event:outputOf; owl:someValuesFrom drug:Prescribing], [ a owl:Restriction; owl:onProperty clinproc:whereinPrescribed; owl:someValuesFrom drug:Package], [ a owl:Restriction; owl:onProperty clinproc:whereinPrescribed; owl:someValuesFrom drug:Dosage], [ a owl:Restriction; owl:onProperty clinproc:whereinPrescribed; owl:someValuesFrom drug:AdministeringFrequency]. drug:Delivering a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug delivering"""@en; skos:definition """Pharmacist handing over a clinical drug to a patient."""@en; rdfs:subClassOf event:Delivering, clinproc:Procedure, [ a owl:Restriction; owl:onProperty agent:hasDonor; owl:someValuesFrom heca:Pharmacist], [ a owl:Restriction; owl:onProperty agent:hasRecipient; owl:someValuesFrom heca:Patient], [ a owl:Restriction; owl:onProperty event:hasOutput; owl:allValuesFrom drug:Delivery]. drug:Delivery a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug delivered"""@en; skos:definition """Clinical drug handed over by a pharmacist to a patient."""@en; rdfs:subClassOf event:Delivery, [ a owl:Restriction; owl:onProperty event:outputOf; owl:someValuesFrom drug:Delivering], [ a owl:Restriction; owl:onProperty event:whereinDelivered; owl:someValuesFrom drug:Package]. drug:DeliveryCondition a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug delivery condition"""@en; skos:definition """Condition to be satisfied in order for a clinical drug to be delivered."""@en; rdfs:subClassOf event:Condition. drug:AdverseReaction a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """adverse drug reaction"""@en; skos:definition """An adverse reaction associated with the use of a clinical drug at a normal dose."""@en; rdfs:subClassOf hurifa:RiskFactor; skos:exactMatch [ a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "106190000"^^clisko:sct20080731DT], [ a skos:Concept; skos:inScheme clisko:icpc2; skos:notation "A85"^^clisko:icpc2DT], [ a skos:Concept; skos:inScheme clisko:icd10; skos:notation "T88.7"^^clisko:icd10DT]. drug:MarketState a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """clinical drug market state"""@en; skos:definition """State of a clinical drug on the pharmaceutical market."""@en; owl:oneOf (drug:onMarket drug:outOfMarket drug:pulledOffMarket drug:marketStateUnknown drug:pulledOffMarketByCompany drug:approvalSuspended). drug:Immunisation a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """immunisation"""@en; skos:definition """Making a human body immune to a pathogen."""@en; owl:intersectionOf (clinproc:PrimaryPreventing drug:Therapy); skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "127785005"^^clisko:sct20080731DT]. drug:ActiveImmunisation a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """active immunisation"""@en; skos:definition """Making a human body immune by letting it form antibodies to a pathogen."""@en; rdfs:subClassOf drug:Immunisation; skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "33879002"^^clisko:sct20080731DT]. drug:Interacting a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """drug interacting"""@en; skos:definition """An interacting involving 2 or more agents of which at least 1 is a clinical drug."""@en; skos:note """Not limited to direct interaction between agents."""@en; rdfs:subClassOf clinproc:Interacting, [ a owl:Restriction; owl:onProperty agent:hasAgent; owl:someValuesFrom drug:Substance], [ a owl:Restriction; owl:onProperty event:hasOutput; owl:someValuesFrom drug:Interaction]. drug:Interaction a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """drug interaction"""@en; skos:definition """Output of drug interacting."""@en; rdfs:subClassOf event:Interaction, [ a owl:Restriction; owl:onProperty event:outputOf; owl:someValuesFrom drug:Interacting], [ a owl:Restriction; owl:onProperty event:hasObject; owl:someValuesFrom clinobs:Finding]. drug:InteractionState a rdfs:Class; rdfs:isDefinedBy ; rdfs:label """interaction state"""@en; skos:definition """State of a clinical drug interaction."""@en; owl:oneOf (drug:interactionDocumented drug:interactionExpected drug:interactionUnlikely drug:interactionUnknown). drug:administrationFormUnit a units:Unit; rdfs:isDefinedBy ; rdfs:label """clinical drug administration form unit"""@en; skos:definition """Clinical drug administration form as unit."""@en; rdfs:comment """E.g. a tablet, a capsule."""@en; skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "408103002"^^clisko:sct20080731DT]. drug:milligramPerTablet a units:Unit, unit:UnitDefinedByProduct; rdfs:isDefinedBy ; rdfs:label """milligram per tablet"""@en; skos:definition """Unit of a concentration of a clinical drug in mg in a tablet."""@en; quant:unitOf [a owl:Restriction; owl:onProperty quant:measurementOf; owl:someValuesFrom quant:Concentration]; mrela:hasOperand units:milligram, drug:perTablet. drug:milligramPerCapsule a units:Unit, unit:UnitDefinedByProduct; rdfs:isDefinedBy ; rdfs:label """milligram per capsule"""@en; skos:definition """Unit of a concentration of a clinical drug in mg in a capsule."""@en; quant:unitOf [a owl:Restriction; owl:onProperty quant:measurementOf; owl:someValuesFrom quant:Concentration]; mrela:hasOperand units:milligram, drug:perCapsule. #drug:microgramPerDose ## do not uncomment without uncommenting perDose # a unit:UnitDefinedByProduct; # rdfs:isDefinedBy ; # rdfs:label """microgram per dose"""@en; # skos:definition """Unit of a concentration of a clinical drug in µg per dose."""@en; # quant:unitOf quant:Concentration; # mrela:hasOperand units:milligram, drug:perDose. drug:perCapsule a unit:UnitDerivedByRaisingToPower; rdfs:isDefinedBy ; rdfs:label """per capsule"""@en; skos:definition """Per capsule as unit of concentration."""@en; mrela:toThePower "-1"^^xsd:double; screla:hasBaseUnit dradfo:Capsule; quant:unitOf [a owl:Restriction; owl:onProperty quant:measurementOf; owl:someValuesFrom quant:Concentration]; skos:exactMatch [a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "428641000"^^clisko:sct20080731DT]. drug:perTablet a unit:UnitDerivedByRaisingToPower; rdfs:isDefinedBy ; rdfs:label """per tablet"""@en; skos:definition """Per tablet as unit of mass concentration."""@en; mrela:toThePower "-1"^^xsd:double; screla:hasBaseUnit dradfo:Tablet; quant:unitOf [a owl:Restriction; owl:onProperty quant:measurementOf; owl:someValuesFrom quant:Concentration]. #drug:perDose ## do not uncomment without uncommenting dose # a unit:UnitDerivedByRaisingToPower; # rdfs:isDefinedBy ; # rdfs:label """per dose"""@en; # skos:definition """Per dose as unit of concentration."""@en; # mrela:toThePower "-1"^^xsd:double; # screla:hasBaseUnit drug:dose; # quant:unitOf [a owl:Restriction; owl:onProperty quant:measurementOf; owl:someValuesFrom quant:Concentration]. drug:freeOfPrescription a drug:DeliveryCondition; rdfs:isDefinedBy ; rdfs:label """free of prescription"""@en; # over-the-counter skos:definition """Clinical drug that can be delivered without the need of a prescription of a medical professional."""@en. drug:subjectToPrescription a drug:DeliveryCondition; rdfs:isDefinedBy ; rdfs:label """subject to prescription"""@en; skos:definition """Clinical drug that can be delivered only on prescription of a medical professional."""@en. # add restriction drug:narcoticDeliveryCondition a drug:DeliveryCondition; rdfs:isDefinedBy ; rdfs:label """narcotic delivery condition"""@en; skos:definition """Narcotic clinical drug that can be delivered only on special prescription of a medical professional."""@en. # add restriction drug:subjectToPrescriptionWithExceptions a drug:DeliveryCondition; rdfs:isDefinedBy ; rdfs:label """subject to prescription with exceptions"""@en; skos:definition """Clinical drug that can be delivered, with some exceptions, only on prescription of a medical professional."""@en. # add restriction drug:interactionDocumented a drug:InteractionState; rdfs:isDefinedBy ; rdfs:label """interaction documented"""@en; skos:definition """ ."""@en. drug:interactionExpected a drug:InteractionState; rdfs:isDefinedBy ; rdfs:label """interaction expected"""@en; skos:definition """ ."""@en. drug:interactionUnknown a drug:InteractionState; rdfs:isDefinedBy ; rdfs:label """interaction unknown"""@en; skos:definition """ ."""@en. drug:interactionUnlikely a drug:InteractionState; rdfs:isDefinedBy ; rdfs:label """interaction unlikely"""@en; skos:definition """ ."""@en. drug:onMarket a drug:MarketState; rdfs:isDefinedBy ; rdfs:label """clinical drug on market"""@en; skos:definition """Clinical drug present on the pharmaceutical market."""@en. drug:outOfMarket a drug:MarketState; rdfs:isDefinedBy ; rdfs:label """clinical drug out of market"""@en; skos:definition """Clinical drug absent from the pharmaceutical market."""@en. drug:pulledOffMarket a drug:MarketState; rdfs:isDefinedBy ; rdfs:label """clinical drug pulled off market"""@en; skos:definition """Clinical drug pulled off the pharmaceutical market."""@en. drug:pulledOffMarketByCompany a drug:MarketState; rdfs:isDefinedBy ; rdfs:label """clinical drug pulled off market by company"""@en; skos:definition """Clinical drug pulled off the pharmaceutical market by the producing pharmaceutical company."""@en. drug:approvalSuspended a drug:MarketState; rdfs:isDefinedBy ; rdfs:label """clinical drug approval suspended"""@en; skos:definition """Clinical drug of which the approval for marketing has been suspended."""@en. drug:marketStateUnknown a drug:MarketState; rdfs:isDefinedBy ; rdfs:label """clinical drug market state unknown"""@en; skos:definition """Clinical drug of which the market state is unknown."""@en. # # PROPERTIES # drug:whereinAdministered a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a drug administered in a clinical therapy."""@en; owl:propertyChainAxiom (event:hasSubProcedure clinproc:whereinAdministered space:contains drug:hasActivePart); rdfs:domain drug:Therapy; rdfs:range drug:Substance. drug:hasGenericName a rdf:Property; rdfs:isDefinedBy ; skos:definition """Specifying a generic name of a clinical drug."""@en; rdfs:subPropertyOf foaf:name; rdfs:domain drug:Substance; rdfs:range rdfs:Literal. drug:hasConcentration # owl:propertyChainAxiom (space:contains drug:hasActivePart drug:hasConcentration) a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a concentration or 'strength' of a drug substance."""@en; rdfs:subPropertyOf quant:hasPhysicalQuantity; rdfs:domain drug:Substance; rdfs:range drug:Concentration. drug:hasActivePart a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a clinical drug as active part of a drug product."""@en; rdfs:subPropertyOf clinproc:hasActivePart; rdfs:domain drug:Product; rdfs:range drug:Substance. drug:activePartOf a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a drug product containing a clinical drug as active part."""@en; owl:inverseOf drug:hasActivePart; rdfs:domain drug:Substance; rdfs:range drug:Product. drug:hasExcipient a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a non active part of a drug product."""@en; rdfs:subPropertyOf space:contains; rdfs:domain drug:Product; rdfs:range drug:Excipient. drug:excipientOf a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a drug product containing a non active part."""@en; rdfs:subPropertyOf space:containedBy; owl:inverseOf drug:hasExcipient; rdfs:domain drug:Excipient; rdfs:range drug:Product. drug:hasUnitsPerPackage a owl:DatatypeProperty; rdfs:isDefinedBy ; skos:definition """Specifying the number of drug administration form units in a package."""@en; rdfs:domain drug:AdministrationForm; rdfs:range xsd:nonNegativeInteger. drug:hasAdministrationForm a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying an administration form of a clinical drug dosage."""@en; rdfs:domain drug:Dosage; rdfs:range drug:AdministrationForm. drug:administrationFormOf a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a clinical drug dosage having a clinical drug administration form."""@en; owl:inverseOf drug:hasAdministrationForm; rdfs:domain drug:AdministrationForm; rdfs:range drug:Dosage. drug:hasDosage a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a clinical drug dosage of an administration."""@en; rdfs:domain drug:Administration; rdfs:range drug:Dosage. drug:dosageOf a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying an administration of a clinical drug dosage."""@en; owl:inverseOf drug:hasDosage; rdfs:domain drug:Dosage; rdfs:range drug:Administration. drug:hasDosageQuantity a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying an administration form quantity of a clinical drug dosage."""@en; rdfs:subPropertyOf quant:hasPhysicalQuantity; rdfs:domain drug:Dosage; rdfs:range drug:DosageQuantity. drug:hasAdministrationSite a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a administration body site of a drug administration form as used in a clinical drug administering."""@en; rdfs:domain drug:AdministrationForm; rdfs:range humanbody:Structure. #drug:batch # a rdf:Property; # rdfs:isDefinedBy ; # skos:definition """Specifying a code of the batch in which a drug was produced."""@en; # rdfs:domain drug:Package; # rdfs:range rdfs:Literal. drug:hasRefills a owl:DatatypeProperty; rdfs:isDefinedBy ; skos:definition """Specifying a number of refills that can be done before a new prescription is needed."""@en; rdfs:domain drug:Package; rdfs:range xsd:nonNegativeInteger. drug:hasAdministrationInstructions a rdf:Property; rdfs:isDefinedBy ; skos:definition """Specifying instructions for clinical drug administration."""@en; rdfs:comment """E.g. '30 min before breakfast'."""@en; rdfs:domain drug:Package; rdfs:range rdfs:Literal. drug:gotPrescribed a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a clinical drug package a patient got prescribed."""@en; rdfs:subPropertyOf clinproc:gotPrescribed; rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Patient]; rdfs:range drug:Package. drug:prescribedFor a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a human patient that got a clinical drug package prescribed."""@en; rdfs:subPropertyOf clinproc:prescribedFor; rdfs:domain drug:Package; rdfs:range [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom heca:Patient]. drug:hasMarketState a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying the market state of a clinical drug as commercially available."""@en; rdfs:domain drug:Package; rdfs:range drug:MarketState. drug:hasDeliveryCondition a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying the delivery condition of a clinical drug as commercially available."""@en; rdfs:domain drug:Package; rdfs:range drug:DeliveryCondition. drug:hasAffectedDrug a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a drug affected by another one with which it is interacting."""@en; rdfs:domain drug:Interacting; rdfs:range drug:Substance. drug:hasAffectingDrug a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a drug affecting another one with which it is interacting."""@en; rdfs:domain drug:Interacting; rdfs:range drug:Substance. drug:hasAffectedDrugInteractionState a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying an affected drug's interaction state."""@en; rdfs:domain drug:Interacting; rdfs:range drug:InteractionState. drug:hasAffectingDrugInteractionState a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying an affecting drug's interaction state."""@en; rdfs:domain drug:Interacting; rdfs:range drug:InteractionState. drug:affects a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a drug affecting another one in an interaction."""@en; rdfs:domain drug:Substance; rdfs:range drug:Substance. drug:interactionOf a owl:ObjectProperty; rdfs:isDefinedBy ; skos:definition """Specifying a drug of an interaction."""@en; rdfs:domain drug:Interaction; rdfs:range drug:Substance.