#
# Prefixes
#

@prefix dce: <http://purl.org/dc/elements/1.1/>.
@prefix owl: <http://www.w3.org/2002/07/owl#>.
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
@prefix skos: <http://www.w3.org/2004/02/skos/core#>.
@prefix fma: <http://sig.biostr.washington.edu/fma3.0#>.

@prefix event: <http://eulersharp.sourceforge.net/2003/03swap/event#>.

@prefix ana: <http://www.agfa.com/w3c/2009/anatomy#>.
@prefix clinobs: <http://www.agfa.com/w3c/2009/clinicalObservation#>.
@prefix clinskosch: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>.

@prefix dis: <http://www.agfa.com/w3c/2009/disorder#>.

<http://www.agfa.com/w3c/2009/disorder#>
	a owl:Ontology;
	dce:title """Disorder"""@en;
	dce:creator """Hans Cools, MD; Pieterjan De Potter"""@en;
	dce:publisher """Agfa Healthcare/Belgium, Ghent University - IBBT/ELIS - Multimedia Lab/Belgium"""@en;
	dce:description """Formal description of human health disorder."""@en;
	dce:format """OWL Full"""@en;
	dce:identifier """dis"""@en;
	dce:language """English"""@en;
	rdfs:comment """Copyright (c) 2009
			Agfa-Gevaert Group / Ghent University - IBBT/ELIS - Multimedia Lab
			All Rights Reserved
			THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF
			Agfa-Gevaert Group/ Ghent University - IBBT/ELIS - Multimedia Lab 
			The copyright notice above does not evidence any
			actual or intended publication of such source code."""@en.

#
# CLASSES
#

dis:Disorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """health disorder"""@en;
	skos:definition """Disorder of a healthy functioning of a human."""@en;
	rdfs:subClassOf clinobs:Finding, event:AdverseProcess, event:Action;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:sct20080731; skos:notation "64572001"^^clinskosch:sct20080731DT], [
		a skos:Concept; skos:inScheme clinskosch:icpc2; skos:notation "A99"^^clinskosch:icpc2DT].	

dis:Neoplasm
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """neoplasm"""@en;
	skos:definition """Abnormal mass of tissue as a result of neoplasia."""@en;
	rdfs:subClassOf dis:Disorder.

dis:MalignantNeoplasm # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """malignant neoplasm"""@en;
	skos:definition """Abnormal mass of tissue as a result of malignant neoplasia."""@en;
	rdfs:subClassOf dis:Neoplasm.

dis:MalignantNeoplasmLymphoidHaematopoieticRelated # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """malignant neoplasm of lymphoid, haematopoietic and related tissue"""@en;
	rdfs:subClassOf dis:MalignantNeoplasm.

dis:LymphoidLeukaemia # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """lymphoid leukaemia"""@en;
	rdfs:subClassOf dis:MalignantNeoplasmLymphoidHaematopoieticRelated.

dis:ImmuneSystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """immune system disorder"""@en;
	rdfs:subClassOf dis:Disorder.

dis:AutoimmuneDisorder # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """autoimmune disorder"""@en;
	skos:definition """Overactive immune response of the human body against sui generis substances."""@en;
	rdfs:subClassOf dis:ImmuneSystemDisorder.

dis:CirculatorySystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """circulatory system disorder"""@en;
	rdfs:subClassOf dis:Disorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:sct20080731; skos:notation "49601007"^^clinskosch:sct20080731DT], [
		a skos:Concept; skos:inScheme clinskosch:icpc2; skos:notation "K99"^^clinskosch:icpc2DT], [
		a skos:Concept; skos:inScheme clinskosch:icd10; skos:notation "I99"^^clinskosch:icd10DT].

dis:HypertensiveDisorder # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """hypertensive disorder"""@en;
	rdfs:subClassOf dis:CirculatorySystemDisorder.

dis:HypertensiveRenalFailure  # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """hypertensive renal failure"""@en;
	rdfs:subClassOf dis:HypertensiveDisorder;
	skos:closeMatch [
		a skos:Concept; skos:inScheme clinskosch:icpc2; skos:notation "K87"^^clinskosch:icpc2DT];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:icd10; skos:notation "I12.0"^^clinskosch:icd10DT].

dis:CerebroVascularDisorder  # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """cerebrovascular disorder"""@en;
	rdfs:subClassOf dis:CirculatorySystemDisorder.

dis:Stroke  # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """stroke"""@en;
	rdfs:subClassOf dis:CerebroVascularDisorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:icpc2; skos:notation "K90"^^clinskosch:icpc2DT], [
		a skos:Concept; skos:inScheme clinskosch:icd10; skos:notation "I64"^^clinskosch:icd10DT].

dis:RespiratorySystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """respiratory system disorder"""@en;
	rdfs:subClassOf dis:Disorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:sct20080731; skos:notation "50043002"^^clinskosch:sct20080731DT], [
		a skos:Concept; skos:inScheme clinskosch:icpc2; skos:notation "R99"^^clinskosch:icpc2DT], [
		a skos:Concept; skos:inScheme clinskosch:icd10; skos:notation "J98.9"^^clinskosch:icd10DT].

dis:UpperRespiratoryTractDisorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """upper repiratory tract disorder"""@en;
	rdfs:subClassOf dis:RespiratorySystemDisorder.

dis:AcuteMaxillarySinusitis  # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """acute maxillary sinusitis"""@en;
	rdfs:subClassOf dis:UpperRespiratoryTractDisorder;
	skos:closeMatch [
		a skos:Concept; skos:inScheme clinskosch:icpc2; skos:notation "R75"^^clinskosch:icpc2DT], [
		a skos:Concept; skos:inScheme clinskosch:icd10; skos:notation "J01.0"^^clinskosch:icd10DT].

dis:LowerRespiratoryTractDisorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """disorder of the lower repiratory system"""@en;
	rdfs:subClassOf dis:RespiratorySystemDisorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:sct20080731; skos:notation "128272009"^^clinskosch:sct20080731DT], [
		a skos:Concept; skos:inScheme clinskosch:icpc2; skos:notation "R99"^^clinskosch:icpc2DT].

dis:LungDisorder   # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """lung disorder"""@en;
	rdfs:subClassOf dis:LowerRespiratoryTractDisorder.
	# clinobs:hasSite fma Lung

dis:Pneumonia # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """pneumonia"""@en;
	skos:definition """Inflammation of any part of the lung parenchyma."""@en;
	rdfs:subClassOf dis:LungDisorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:sct20080731; skos:notation "205237003"^^clinskosch:sct20080731DT].

dis:IdiosyncraticAsthma   # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:subClassOf dis:LowerRespiratoryTractDisorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:icpc2; skos:notation "R96"^^clinskosch:icpc2DT], [
		a skos:Concept; skos:inScheme clinskosch:icd10; skos:notation "J45.1"^^clinskosch:icd10DT].

dis:GenitourinarySystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """disorder of the genuitourinary system"""@en;
	rdfs:subClassOf dis:Disorder, [
		a owl:Restriction; owl:onProperty clinobs:hasSite; owl:allValuesFrom ana:GenitourinarySystemStructure];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:sct20080731; skos:notation "42030000"^^clinskosch:sct20080731DT], [
		a skos:Concept; skos:inScheme clinskosch:icd10; skos:notation "N99.9"^^clinskosch:icd10DT].

dis:UrinarySystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """disorder of the urinary system"""@en;
	rdfs:subClassOf dis:GenitourinarySystemDisorder, [
		a owl:Restriction; owl:onProperty clinobs:hasSite; owl:allValuesFrom ana:UrinarySystemStructure];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:sct20080731; skos:notation "128606002"^^clinskosch:sct20080731DT], [
		a skos:Concept; skos:inScheme clinskosch:icpc2; skos:notation "U99"^^clinskosch:icpc2DT], [
		a skos:Concept; skos:inScheme clinskosch:icd10; skos:notation "N39.9"^^clinskosch:icd10DT].

dis:UpperUrinaryTractDisorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """disorder of the upper urinary tract"""@en;
	rdfs:subClassOf dis:UrinarySystemDisorder.

dis:LowerUrinaryTractDisorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """disorder of the lower urinary tract"""@en;
	rdfs:subClassOf dis:UrinarySystemDisorder;
	rdfs:subClassOf [
		a owl:Restriction; owl:onProperty clinobs:hasSite; owl:allValuesFrom ana:LowerUrinaryTractStructure];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:sct20080731; skos:notation "7793005"^^clinskosch:sct20080731DT].

dis:Cystitis   # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """cystitis"""@en;
	skos:definition """Inflammation of the urinary bladder."""@en;
	rdfs:subClassOf dis:LowerUrinaryTractDisorder;
	rdfs:subClassOf [
		a owl:Restriction; owl:onProperty clinobs:hasSite; owl:allValuesFrom fma:Urinary_bladder].

dis:NervousSystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """nervous system disorder"""@en;
	rdfs:subClassOf dis:Disorder.

dis:CentralNervousSystemDisorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """central nervous system disorder"""@en;
	rdfs:subClassOf dis:NervousSystemDisorder.

dis:MusculoskeletalDisorder
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:label """musculoskeletal disorder"""@en;
	rdfs:subClassOf dis:Disorder.

dis:Sciatica   # example; to be transferred to other namespace
	a rdfs:Class;
	rdfs:isDefinedBy dis:;
	rdfs:subClassOf dis:MusculoskeletalDisorder;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:icpc2; skos:notation "L86"^^clinskosch:icpc2DT], [
		a skos:Concept; skos:inScheme clinskosch:icd10; skos:notation "M54.3"^^clinskosch:icd10DT].

#
# INSTANCES
#

dis:acute
	a event:OnsetMode, event:CourseMode;
	rdfs:isDefinedBy dis:;
	rdfs:label """acute"""@en;
	skos:definition """Having a rapid onset and following a short but severe course."""@en;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clinskosch:sct20080731; skos:notation "373933003"^^clinskosch:sct20080731DT].