@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>. @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>. @prefix owl: <http://www.w3.org/2002/07/owl#>. @prefix dce: <http://purl.org/dc/elements/1.1/>. @prefix skos: <http://www.w3.org/2004/02/skos/core#>. @prefix event: <http://eulersharp.sourceforge.net/2003/03swap/event#>. @prefix agent: <http://eulersharp.sourceforge.net/2003/03swap/agent#>. @prefix env: <http://eulersharp.sourceforge.net/2003/03swap/environment#>. @prefix clisko: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>. @prefix heca: <http://www.agfa.com/w3c/2009/healthCare#>. @prefix clinproc: <http://www.agfa.com/w3c/2009/clinicalProcedure#>. @prefix ther: <http://www.agfa.com/w3c/2009/therapy#>. @prefix clintrial: <http://www.agfa.com/w3c/2009/clinicalTrial#>. <http://www.agfa.com/w3c/2009/clinicalTrial> a owl:Ontology; dce:title """Clinical Trial"""@en; dce:creator """Hans Cools, MD; Agfa Healthcare/Belgium"""@en; dce:publisher """Agfa Healthcare/Belgium"""@en; dce:description """Formal general description of clinical trial."""@en; dce:format """OWL-Full"""@en; rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group / Ghent University - IBBT/ELIS - Multimedia Lab All Rights Reserved THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group/ Ghent University - IBBT/ELIS - Multimedia Lab The copyright notice above does not evidence any actual or intended publication of such source code."""@en; skos:note """There are properties with a list as range. A list keeps things together in a better way than a blank node and improves reasoning performance. List content is tripled when needed, e.g. to permit SPARQL querying."""@en. # # CLASSES # clintrial:Trial a rdfs:Class; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; rdfs:label """clinical trial"""@en; skos:definition """Clinical procedure performed to allow safety and efficacy data to be collected for health care interventions."""@en; rdfs:subClassOf ther:Therapy; # clinproc:Procedure skos:exactMatch [ a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "110465008"^^clisko:sct20080731DT]. clintrial:Environment a rdfs:Class; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; rdfs:label """clinical trial environment"""@en; skos:definition """Health care environment wherein a clinical trial is performed."""@en; rdfs:subClassOf heca:Environment. clintrial:Patient a rdfs:Class; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; rdfs:label """clinical trial patient"""@en; skos:definition """Role of patient in a clinical trial."""@en; rdfs:subClassOf heca:Patient. # TO DO: # types: # Prevention trial: look for better ways to prevent disease in people who have never had the disease or to prevent a disease from returning. These approaches may include medicines, vitamins, vaccines, minerals, or lifestyle changes. # Screening trial: test the best way to detect certain diseases or health conditions. # Diagnostic trial: conducted to find better tests or procedures for diagnosing a particular disease or condition. # Treatment trial: test experimental treatments, new combinations of drugs, or new approaches to surgery or radiation therapy. # Quality of life trial: explore ways to improve comfort and the quality of life for individuals with a chronic illness (a.k.a. Supportive Care trials). # Compassionate use trials or expanded access: provide partially tested, unapproved therapeutics prior to a small number of patients that have no other realistic options. Usually, this involves a disease for which no effective therapy exists, or a patient that has already attempted and failed all other standard treatments and whose health is so poor that he does not qualify for participation in randomized clinical trials. # Clinical trials involving new drugs are commonly classified into four phases. clintrial:Investigator a rdfs:Class; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; rdfs:label """clinical trial investigator"""@en; skos:definition """Role of performing research in a clinical trial."""@en; rdfs:subClassOf heca:Professional. clintrial:CoordinatingInvestigator # to lift up to (clinical) research? a rdfs:Class; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; rdfs:label """clinical trial coordinating investigator"""@en; skos:definition """Role of coordinating a clinical trial in a health care environment using good clinical practice, and reporting data to a funding organization."""@en; rdfs:subClassOf clintrial:Investigator. clintrial:PrincipalInvestigator # to lift up to (clinical) research? a rdfs:Class; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; rdfs:label """clinical trial principal investigator"""@en; skos:definition """Role being responsible for completion of a clinical trial in 1 site, directing it and reporting to a coordinating investigator."""@en; rdfs:subClassOf clintrial:Investigator. clintrial:Subinvestigator # to lift up to (clinical) research? a rdfs:Class; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; rdfs:label """clinical trial sub-investigator"""@en; skos:definition """Role of performing research in a clinical trial, reporting to principal investigator."""@en; rdfs:subClassOf clintrial:Investigator. # # PROPERTIES # clintrial:hasSubject a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a patient subject in a clinical trial."""@en; rdfs:domain clintrial:Trial; rdfs:range [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:Patient]. clintrial:subjectIn a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a clinical trial a patient is subject in."""@en; rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:Patient]; rdfs:range clintrial:Trial. clintrial:entersDuring a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a period wherein a patient enters a clinical trial as subject."""@en; rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:Patient]; rdfs:range event:Event. clintrial:hasEnteringPeriodMargin a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Linking a clinical trial patient to a list with beginning and end date time typed literals of a period wherein the patient enters the trial as subject."""@en; rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:Patient]; rdfs:range rdf:List. clintrial:leavesDuring a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a period wherein a patient leaves a clinical trial as subject."""@en; rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:Patient]; rdfs:range event:Event. clintrial:hasLeavingPeriodMargin a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Linking a clinical trial patient to a list with beginning and end date time typed literals of a period wherein the patient leaves the trial as subject."""@en; rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:Patient]; rdfs:range rdf:List. clintrial:participatesDuring a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a period wherein a patient participates in a clinical trial as subject."""@en; rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:Patient]; rdfs:range event:Event. clintrial:hasParticipatingPeriodMargin a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Linking a clinical trial patient to a list with beginning and end date time typed literals of a period wherein the patient participates in the trial as subject."""@en; rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:Patient]; rdfs:range rdf:List. clintrial:hasSubjectEnteringDuring a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a period wherein a clinical trial has a patient entering as subject."""@en; rdfs:domain clintrial:Trial; rdfs:range event:Event. clintrial:hasSubjectEnteringPeriodMargin a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Linking a clinical trial to a list with beginning and end date time typed literals of a period wherein a patient enters the trial as subject."""@en; rdfs:domain clintrial:Trial; rdfs:range rdf:List. clintrial:hasSubjectLeavingDuring a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a period wherein a clinical trial has a patient leaving as subject."""@en; rdfs:domain clintrial:Trial; rdfs:range event:Event. clintrial:hasSubjectLeavingPeriodMargin a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Linking a clinical trial to a list with beginning and end date time typed literals of a period wherein a patient leaves the trial as subject."""@en; rdfs:domain clintrial:Trial; rdfs:range rdf:List. clintrial:hasEnvironment a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying an environment wherein a clinical trial is performed."""@en; rdfs:subPropertyOf env:hasEnvironment; rdfs:domain clintrial:Trial; rdfs:range clintrial:Environment. clintrial:environmentOf a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a clinical trial performed in an environment."""@en; rdfs:subPropertyOf env:environmentOf; owl:inverseOf clintrial:hasEnvironment; rdfs:domain clintrial:Environment; rdfs:range clintrial:Trial. clintrial:investigatesIn a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a clinical trial a person investigates in."""@en; rdfs:subPropertyOf agent:actsIn; rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:Investigator]; rdfs:range clintrial:Trial. clintrial:hasInvestigator a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a person investigating in a clinical trial."""@en; rdfs:subPropertyOf agent:hasAgent; owl:inverseOf clintrial:investigatesIn; rdfs:domain clintrial:Trial; rdfs:range [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:Investigator]. clintrial:coordinates a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a clinical trial coordinated by a person."""@en; rdfs:subPropertyOf agent:actsIn; rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:CoordinatingInvestigator]; rdfs:range clintrial:Trial. clintrial:coordinatedBy a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a person coordinating a clinical trial."""@en; rdfs:subPropertyOf agent:hasAgent; owl:inverseOf clintrial:coordinates; rdfs:domain clintrial:Trial; rdfs:range [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:CoordinatingInvestigator]. clintrial:responsibleFor a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a clinical trial a person is principal investigator of."""@en; rdfs:subPropertyOf agent:actsIn; rdfs:domain [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:PrincipalInvestigator]; rdfs:range clintrial:Trial. clintrial:hasResponsible a owl:ObjectProperty; rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/clinicalTrial#>; skos:definition """Specifying a person being principal investigator of a clinical trial."""@en; rdfs:subPropertyOf agent:hasAgent; owl:inverseOf clintrial:responsibleFor; rdfs:domain clintrial:Trial; rdfs:range [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom clintrial:PrincipalInvestigator].