@prefix dce: <http://purl.org/dc/elements/1.1/>.
@prefix owl: <http://www.w3.org/2002/07/owl#>.
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
@prefix skos: <http://www.w3.org/2004/02/skos/core#>.
@prefix clisko: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>.
@prefix event: <http://eulersharp.sourceforge.net/2003/03swap/event#>.
@prefix clineva: <http://www.agfa.com/w3c/2009/clinicalEvaluation#>.
@prefix hurifa: <http://www.agfa.com/w3c/2009/humanRiskFactors#>.
@prefix humdis: <http://www.agfa.com/w3c/2009/humanDisorder#>.
@prefix lymphoma: <http://www.agfa.com/w3c/2009/lymphoma#>.
@prefix leuther: <http://www.agfa.com/w3c/2009/leukemiaTherapy#>.
@prefix leukemia: <http://www.agfa.com/w3c/2009/leukemia#>.
@prefix ther: <http://www.agfa.com/w3c/2009/therapy#>.
@prefix chemo: <http://www.agfa.com/w3c/2009/chemotherapy#>.
@prefix cll: <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>.

<http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia>
	a owl:Ontology;
	dce:title """Chronic Lymphocytic Leukemia"""@en;
	dce:creator """Hans Cools, MD, Agfa Healthcare/Belgium"""@en;
	dce:contributor """Susanne Isfort, MD, University Clinic of Cologne; Julia von Tresckow, MD, University Clinic of Cologne"""@en;
	dce:publisher """Agfa Healthcare/Belgium"""@en;
	dce:description """Formal description of chronic lymphocytic leukemia and related concepts."""@en;
	dce:format """OWL Full"""@en;
	rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group All Rights Reserved. THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group The copyright notice above does not evidence any actual or intended publication of such source code."""@en.

#
# CLASSES
#

cll:BCellChronicLymphocyticLeukemia
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """B-cell chronic lymphocytic leukemia"""@en;
	skos:definition """Slowly progressing B-cell lymphoid leukaemia."""@en;
	rdfs:subClassOf leukemia:LymphoidLeukaemia, [
		a owl:Restriction; owl:onProperty clineva:hasStage; owl:someValuesFrom cll:BinetStage], [
		a owl:Restriction; owl:onProperty event:hasCourseMode; owl:someValuesFrom event:Persistent];
	owl:unionOf ([
		a owl:Restriction; owl:onProperty humdis:transformsIn; owl:someValuesFrom cll:BCellProlymphocyticLeukemia] [
		a owl:Restriction; owl:onProperty humdis:transformsIn; owl:someValuesFrom lymphoma:DiffuseLargeBCellLymphoma] [
		a owl:Restriction; owl:onProperty humdis:transformsIn; owl:someValuesFrom lymphoma:Hodgkin]);
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "92814006"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "C91.1"^^clisko:icd10DT].

cll:BCellChronicLymphocyticLeukemiaCompleteRemission
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """B-cell chronic lymphocytic leukemia in comlete remission"""@en;
	skos:definition """B-cell chronic lymphocytic leukemia without detectable disorder."""@en;
	rdfs:subClassOf cll:BCellChronicLymphocyticLeukemia;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "C91.11"^^clisko:icd10DT].

cll:BCellChronicLymphocyticLeukemiaWithoutRemission
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """B-cell chronic lymphocytic leukemia without remission"""@en;
	skos:definition """B-cell chronic lymphocytic leukemia without remission."""@en;
	rdfs:subClassOf cll:BCellChronicLymphocyticLeukemia;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "C91.10"^^clisko:icd10DT].

cll:BCellProlymphocyticLeukemia
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """B-cell prolymphocytic leukemia"""@en;
	skos:definition """More aggressive transformation of B-cell chronic lymphocytic leukemia."""@en;
	rdfs:subClassOf leukemia:LymphoidLeukaemia, [
		a owl:Restriction; owl:onProperty humdis:isTransformationOf; owl:someValuesFrom cll:BCellChronicLymphocyticLeukemia];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "277619001"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "C91.3"^^clisko:icd10DT].

cll:RichterSyndrome
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """Richter's syndrome"""@en;
	skos:definition """Transformation of B-cell chronic lymphocytic leukemia into more aggressive lymphoma."""@en;
	rdfs:subClassOf [
		a owl:Restriction; owl:onProperty humdis:hasTransformationOf; owl:someValuesFrom [
			rdfs:subClassOf cll:BCellChronicLymphocyticLeukemia, [
				owl:disjointUnionOf ([
					a owl:Restriction; owl:onProperty humdis:transformsIn; owl:someValuesFrom lymphoma:DiffuseLargeBCellLymphoma] [
					a owl:Restriction; owl:onProperty humdis:transformsIn; owl:someValuesFrom lymphoma:Hodgkin])]]].

cll:BinetStaging
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """Binet staging"""@en;
	skos:definition """Clinical staging of chronic lymphocitic leukemia, based on I) the number of involved areas, A) defined by the presence of enlarged lymph nodes greater than 1 cm in diameter in 1) head/neck/Waldeyer ring, 2) axillae, 3) groins, including superficial femorals, or B) organomegaly of spleen, liver, and II) on whether there is anemia or thrombocytopenia."""@en;
	rdfs:subClassOf clineva:Staging.

cll:BinetStage
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """Binet stage"""@en;
	skos:definition """Output of Binet staging."""@en;
	rdfs:subClassOf clineva:Stage, [
		a owl:Restriction; owl:onProperty event:outputOf; owl:someValuesFrom cll:BinetStaging];
	owl:oneOf (cll:BinetStageA cll:BinetStageB cll:BinetStageC).

cll:BinetStageA
	a rdfs:Class, cll:BinetStage;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """Binet stage A"""@en;
	skos:definition """Output of Binet staging based on hemoglobin concentration measurement value >= 100 g/L AND thrombocyte count value >= 100 1e9/L AND =< 3 involved areas."""@en.

cll:BinetStageB
	a rdfs:Class, cll:BinetStage;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """Binet stage B"""@en;
	skos:definition """Output of Binet staging based on hemoglobin concentration measurement value >= 100 g/L AND thrombocyte count value >= 100 1e9/L AND >= 3 involved areas."""@en.

cll:BinetStageC
	a rdfs:Class, cll:BinetStage;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """Binet stage C"""@en;
	skos:definition """Output of Binet staging based on hemoglobin concentration measurement value < 100 g/L AND thrombocyte count value < 100 1e9/L; involved areas irrelevant."""@en.

cll:CIRS
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "Cumulative illness rating scale"@en;
	rdfs:subClassOf clineva:Stage.

cll:CIRS0
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 0"@en.

cll:CIRS1
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 1"@en.

cll:CIRS2
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 2"@en.

cll:CIRS3
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 3"@en.

cll:CIRS4
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 4"@en.

cll:CIRS5
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 5"@en.

cll:CIRS6
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 6"@en.

cll:CIRS7
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 7"@en.

cll:CIRS8
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 8"@en.

cll:CIRS9
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 9"@en.

cll:CIRS10
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 10"@en.

cll:CIRS11
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 11"@en.

cll:CIRS12
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 12"@en.

cll:CIRS13
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 13"@en.

cll:CIRS14
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 14"@en.

cll:CIRS15
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 15"@en.

cll:CIRS16
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 16"@en.

cll:CIRS17
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 17"@en.

cll:CIRS18
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 18"@en.

cll:CIRS19
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 19"@en.

cll:CIRS20
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 20"@en.

cll:CIRS21
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 21"@en.

cll:CIRS22
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 22"@en.

cll:CIRS23
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 23"@en.

cll:CIRS24
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 24"@en.

cll:CIRS25
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 25"@en.

cll:CIRS26
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 26"@en.

cll:CIRS27
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 27"@en.

cll:CIRS28
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 28"@en.

cll:CIRS29
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 29"@en.

cll:CIRS30
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 30"@en.

cll:CIRS31
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 31"@en.

cll:CIRS32
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 32"@en.

cll:CIRS33
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 33"@en.

cll:CIRS34
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 34"@en.

cll:CIRS35
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 35"@en.

cll:CIRS36
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 36"@en.

cll:CIRS37
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 37"@en.

cll:CIRS38
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 38"@en.

cll:CIRS39
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 39"@en.

cll:CIRS40
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 40"@en.

cll:CIRS41
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 41"@en.

cll:CIRS42
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 42"@en.

cll:CIRS43
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 43"@en.

cll:CIRS44
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 44"@en.

cll:CIRS45
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 45"@en.

cll:CIRS46
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 46"@en.

cll:CIRS47
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 47"@en.

cll:CIRS48
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 48"@en.

cll:CIRS49
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 49"@en.

cll:CIRS50
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 50"@en.

cll:CIRS51
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 51"@en.

cll:CIRS52
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 52"@en.

cll:CIRS53
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 53"@en.

cll:CIRS54
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 54"@en.

cll:CIRS55
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 55"@en.

cll:CIRS56
	a rdfs:Class, cll:CIRS;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label "CIRS score 56"@en.

cll:StandardTherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """standard chemotherapy for chronic lymphocytic leukemia"""@en;
	skos:definition """Chemotherapy implying administration of a drug to a chronic lymphocytic leukemia patient."""@en;
	rdfs:subClassOf chemo:Therapy.

cll:StandardNonComorbidTherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """standard chemotherapy for chronic lymphocytic leukemia in non-comorbid patient"""@en;
	skos:definition """Chemotherapy implying administration of a drug(s) to a non-comorbid chronic lymphocytic leukemia patient, e.g. FCR (fludarabine, cyclophosphamide, rituximab)."""@en;
	rdfs:subClassOf cll:StandardTherapy.

cll:StandardComorbidTherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/chronicLymphocyticLeukemia#>;
	rdfs:label """standard chemotherapy for chronic lymphocytic leukemia in comorbid patient"""@en;
	skos:definition """Chemotherapy implying administration of a drug to a comorbid chronic lymphocytic leukemia patient, e.g. chlorambucil."""@en;
	rdfs:subClassOf cll:StandardTherapy.