@prefix dce: <http://purl.org/dc/elements/1.1/>.
@prefix owl: <http://www.w3.org/2002/07/owl#>.
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
@prefix skos: <http://www.w3.org/2004/02/skos/core#>.
@prefix clisko: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>.
@prefix event: <http://eulersharp.sourceforge.net/2003/03swap/event#>.
@prefix clineva: <http://www.agfa.com/w3c/2009/clinicalEvaluation#>.
@prefix malneo: <http://www.agfa.com/w3c/2009/malignantNeoplasm#>.
@prefix breca: <http://www.agfa.com/w3c/2009/breastCarcinoma#>.

<http://www.agfa.com/w3c/2009/breastCarcinoma>
	a owl:Ontology;
	dce:title """Breast carcinoma"""@en;
	dce:creator """Hans Cools, MD; Agfa Healthcare/Belgium"""@en;
	dce:publisher """Agfa Healthcare/Belgium"""@en;
	dce:description """Formal description of breast carcinoma."""@en;
	dce:format """OWL Full"""@en;
	rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group All Rights Reserved. THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group The copyright notice above does not evidence any actual or intended publication of such source code."""@en.

#
# CLASSES
#

breca:BreastCarcinoma
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/breastCarcinoma#>;
	rdfs:label """breast carcinoma"""@en;
	skos:definition """Malignant neoplasia originating from breast tissue."""@en;
	rdfs:subClassOf malneo:MalignantNeoplasia;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "254838004"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:icd10; skos:notation "C50"^^clisko:icd10DT].

# breca:BreastAdenocarcinoma

breca:NottinghamGrading
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/breastCarcinoma#>;
	rdfs:label """Nottingham grading"""@en;
	skos:definition """Histological staging of breast carcinoma based on tubule formation, mitotic count and nuclear pleomorphism."""@en;
	rdfs:subClassOf clineva:HistologicalStaging.

breca:NottinghamGrade
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/breastCarcinoma#>;
	rdfs:label """Nottingham grade"""@en;
	skos:definition """Histological stage of breast carcinoma based on tubule formation, mitotic count and nuclear pleomorphism."""@en;
	rdfs:subClassOf clineva:HistologicalStage.

# sample -> histological exam object:

# breca:HistologicalFinding

breca:TubuleFormation
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/breastCarcinoma#>;
	rdfs:label """tubule formation"""@en;
	skos:definition """Formation of tubules in a breast carcinoma."""@en.

breca:strongTubuleFormation	# ? measurable -> calculate %
	a rdfs:Class, breca:TubuleFormation;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/breastCarcinoma#>;
	rdfs:label """strong tubule formation"""@en;
	skos:definition """> 75% of breast carcinoma consists of tubuli."""@en.

breca:moderateTubuleFormation
	a rdfs:Class, breca:TubuleFormation;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/breastCarcinoma#>;
	rdfs:label """moderate tubule formation"""@en;
	skos:definition """10-75% of breast carcinoma consists of tubuli."""@en.

breca:littleTubuleFormation
	a rdfs:Class, breca:TubuleFormation;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/breastCarcinoma#>;
	rdfs:label """little tubule formation"""@en;
	skos:definition """< 10% of breast carcinoma consists of tubuli."""@en.


# breca:NuclearPleomorphism

# breca:SmallRegularUniformCell

# breca:ModerateNuclearSizeAndVariation

# breca:MarkedNuclearVariation