@prefix dce: <http://purl.org/dc/elements/1.1/>.
@prefix owl: <http://www.w3.org/2002/07/owl#>.
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
@prefix skos: <http://www.w3.org/2004/02/skos/core#>.
@prefix agent: <http://eulersharp.sourceforge.net/2003/03swap/agent#>.
@prefix fos: <http://eulersharp.sourceforge.net/2003/03swap/foster#>.
@prefix clisko: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>.
@prefix drug: <http://www.agfa.com/w3c/2009/drugTherapy#>.
@prefix abther: <http://www.agfa.com/w3c/2009/antibioticTherapy#>.
@prefix antibio: <http://www.agfa.com/w3c/2009/antibiotics#>.

<http://www.agfa.com/w3c/2009/antibiotics>
	a owl:Ontology;
	dce:title """Antibiotics"""@en;
	dce:creator """Hans Cools, MD; Agfa Healthcare/Belgium"""@en;
	dce:contributor """Until 2010: Pieterjan De Potter; Ghent University - IBBT/ELIS - Multimedia Lab/Belgium"""@en;
	dce:publisher """Agfa Healthcare/Belgium"""@en;
	dce:description """Formal description of antibiotics as applied in human medicine."""@en;
	dce:format """OWL Full"""@en;
	rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group / Ghent University - IBBT/ELIS - Multimedia Lab All Rights Reserved THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group/ Ghent University - IBBT/ELIS - Multimedia Lab The copyright notice above does not evidence any actual or intended publication of such source code."""@en.

#
# CLASSES
#

antibio:Rifamycin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """rifamycin"""@en;
	rdfs:subClassOf [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:Antibiotic].

antibio:Rifampicin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """rifampicin"""@en;
	rdfs:subClassOf antibio:Rifamycin;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "29175007"^^clisko:sct20080731DT].

antibio:Quinolone
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """quinolone"""@en;
	rdfs:subClassOf [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:Antibiotic];
	rdfs:subClassOf [
		a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:BroadSpectrum];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "37084008"^^clisko:sct20080731DT].

# NalidixicAcid: 1st generation quinolone

antibio:Fluoroquinolone
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """fluoroquinolone"""@en;
	rdfs:subClassOf antibio:Quinolone;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "37084008"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01MA"^^clisko:atc20090101DT].

antibio:Ciprofloxacin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """ciprofloxacin"""@en;
	rdfs:comment """2nd generation quinolone"""@en;
	rdfs:subClassOf antibio:Fluoroquinolone;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "7577004"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01MA02"^^clisko:atc20090101DT].
	
antibio:Levofloxacin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """levofloxacin"""@en;
	rdfs:comment """3rd generation quinolone"""@en;
	rdfs:subClassOf antibio:Fluoroquinolone;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "96087006"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01MA12"^^clisko:atc20090101DT].

antibio:Lomefloxacin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """lomefloxacin"""@en;
	rdfs:comment """2nd generation quinolone"""@en;
	rdfs:subClassOf antibio:Fluoroquinolone;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "96088001"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01MA07"^^clisko:atc20090101DT].

antibio:Norfloxacin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """norfloxacin"""@en;
	rdfs:comment """2nd generation quinolone"""@en;
	rdfs:subClassOf antibio:Fluoroquinolone;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "49485009"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01MA06"^^clisko:atc20090101DT].

antibio:Ofloxacin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """ofloxacin"""@en;
	rdfs:comment """2nd generation quinolone"""@en;
	rdfs:subClassOf antibio:Fluoroquinolone;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "96086002"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01MA01"^^clisko:atc20090101DT].

antibio:Trimethoprim
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """trimethoprim"""@en;
	rdfs:comment """First choice antibiotic for non-cmplicated lower urinary tract infection of the adult female."""@en;
	rdfs:subClassOf [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:Antibiotic];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01EA01"^^clisko:atc20090101DT], [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "32792001"^^clisko:sct20080731DT].

antibio:Sulfonamide
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """sulfonamide"""@en;
	rdfs:subClassOf [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:Antibiotic];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "59255006"^^clisko:sct20080731DT].

antibio:SulfonamideMedium
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """intermediate-acting sulfonamide"""@en;
	rdfs:subClassOf antibio:Sulfonamide;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01EC"^^clisko:atc20090101DT].
	
antibio:Sulfamethoxazole
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """sulfamethoxazole"""@en;
	rdfs:subClassOf antibio:SulfonamideMedium;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "70047000"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01EC01"^^clisko:atc20090101DT].

antibio:CoTrimoxazole
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """co-trimoxazole"""@en;
	rdfs:subClassOf drug:Compound;
	owl:intersectionOf ([
		a owl:Restriction; owl:onProperty drug:hasActivePart; owl:someValuesFrom antibio:Sulfamethoxazole][
		a owl:Restriction; owl:onProperty drug:hasActivePart; owl:someValuesFrom antibio:Trimethoprim]);	
	rdfs:subClassOf [
		a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:BroadSpectrum];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "398731002"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01EE01"^^clisko:atc20090101DT].

antibio:Nitrofurantoin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """nitrofurantoin"""@en;
	rdfs:comment """First choice antibiotic for non-complicated lower urinary tract infection of the adult female."""@en;
	rdfs:comment """Also active against anaerobe bacteria."""@en;
	rdfs:subClassOf [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:Antibiotic];
	rdfs:subClassOf [
		a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:BroadSpectrum];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "85343003"^^clisko:sct20080731DT].

antibio:Beta-lactamAntibiotic
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """beta-lactam antibiotic"""@en;
	rdfs:subClassOf [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:Antibiotic];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "373297006"^^clisko:sct20080731DT].

antibio:Cephalosporin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """cephalosporin"""@en;
	rdfs:subClassOf antibio:Beta-lactamAntibiotic;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "51779009"^^clisko:sct20080731DT].

antibio:Cephalosporin3
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """3rd generation cephalosporin"""@en;
	rdfs:subClassOf antibio:Cephalosporin;
	rdfs:subClassOf [
		a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:BroadSpectrum].

antibio:Ceftriaxone
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """ceftriaxone"""@en;
	rdfs:comment """First choice antibiotic for bacterial meningitis."""@en;
	rdfs:subClassOf antibio:Cephalosporin3;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "372670001"^^clisko:sct20080731DT].

antibio:Penicillin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """penicillin"""@en;
	rdfs:subClassOf antibio:Beta-lactamAntibiotic;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "6369005"^^clisko:sct20080731DT].

antibio:NarrowSpectrumPenicillin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """narrow spectrum penicillin"""@en;
	rdfs:subClassOf antibio:Penicillin, [
		a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:NarrowSpectrum].

antibio:PenicillinaseSensitivePenicillin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """penicillinase sensitive penicillin"""@en;
	rdfs:subClassOf antibio:NarrowSpectrumPenicillin.

antibio:Phenoxymethylpenicillin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """phenoxymethylpenicillin"""@en;
	rdfs:subClassOf antibio:PenicillinaseSensitivePenicillin;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "78507004"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01CE10"^^clisko:atc20090101DT].

antibio:Benzylpenicillin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """benzylpenicillin"""@en;
	rdfs:subClassOf antibio:PenicillinaseSensitivePenicillin;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "78507004"^^clisko:sct20080731DT].

antibio:Clometocillin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """clometocillin"""@en;
	rdfs:subClassOf antibio:Benzylpenicillin;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01CE07"^^clisko:atc20090101DT].

antibio:Aminopenicillin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	rdfs:label """aminopenicillin"""@en;
	rdfs:subClassOf antibio:Penicillin;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "373298001"^^clisko:sct20080731DT].

antibio:Amoxicillin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """amoxicillin"""@en;
	rdfs:subClassOf antibio:Aminopenicillin;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "27658006"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01CA04"^^clisko:atc20090101DT].

antibio:Fosfomycin
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibiotics#>;
	drug:hasGenericName """fosfomycin"""@en;
	rdfs:subClassOf [a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:Antibiotic];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "372534005"^^clisko:sct20080731DT], [
		a skos:Concept; skos:inScheme clisko:atc20090101; skos:notation "J01XX01"^^clisko:atc20090101DT].