@prefix dce: <http://purl.org/dc/elements/1.1/>.
@prefix owl: <http://www.w3.org/2002/07/owl#>.
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>.
@prefix skos: <http://www.w3.org/2004/02/skos/core#>.
@prefix agent: <http://eulersharp.sourceforge.net/2003/03swap/agent#>.
@prefix event: <http://eulersharp.sourceforge.net/2003/03swap/event#>.
@prefix fos: <http://eulersharp.sourceforge.net/2003/03swap/foster#>.
@prefix space: <http://eulersharp.sourceforge.net/2003/03swap/space#>.
@prefix clisko: <http://www.agfa.com/w3c/2009/clinicalSKOSSchemes#>.
@prefix ther: <http://www.agfa.com/w3c/2009/therapy#>.
@prefix drug: <http://www.agfa.com/w3c/2009/drugTherapy#>.
@prefix infdis: <http://www.agfa.com/w3c/2009/infectiousDisorder#>.
@prefix abther: <http://www.agfa.com/w3c/2009/antibioticTherapy#>.

<http://www.agfa.com/w3c/2009/antibioticTherapy>
	a owl:Ontology;
	dce:title """Antibiotic Therapy"""@en;
	dce:creator """Hans Cools, MD, Agfa Healthcare/Belgium"""@en;
	dce:publisher """Agfa Healthcare/Belgium"""@en;
	dce:description """Formal general description of antibiotic therapy as applied in human medicine."""@en;
	dce:format """OWL Full"""@en;
	rdfs:comment """Copyright (c) 2009 Agfa-Gevaert Group / All Rights Reserved. THIS IS UNPUBLISHED PROPRIETARY SOURCE CODE OF Agfa-Gevaert Group/ The copyright notice above does not evidence any actual or intended publication of such source code."""@en.

#
# CLASSES
#

abther:Therapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibioticTherapy#>;
	rdfs:label """antibiotic therapy"""@en;
	skos:definition """Clinical therapy implying administration of an antibiotic."""@en;
	rdfs:subClassOf drug:Therapy, [
		a owl:Restriction; owl:onProperty ther:usedToTreat; owl:someValuesFrom infdis:Infection], [
		a owl:Restriction; owl:onProperty event:hasSubProcedure; owl:someValuesFrom abther:Administering];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "281789004"^^clisko:sct20080731DT].

abther:EmpiricalTherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibioticTherapy#>;
	rdfs:label """empirical antibiotic therapy"""@en;
	skos:definition """Antibiotic therapy without knowing the infecting bacterium's identity and its antibiotic susceptibility."""@en;
	rdfs:subClassOf abther:Therapy;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "371070000"^^clisko:sct20080731DT].

abther:CultureBasedTherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibioticTherapy#>;
	rdfs:label """culture based antibiotic therapy"""@en;
	skos:definition """Antibiotic therapy based on the evaluation of a bacterial culture."""@en;
	rdfs:subClassOf abther:Therapy.

abther:AntibiogramBasedTherapy
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibioticTherapy#>;
	rdfs:label """antibiogram based antibiotic therapy"""@en;
	skos:definition """Antibiotic therapy based on the evaluation of an antibiogram."""@en;
	rdfs:subClassOf abther:Therapy, ther:TargetedTherapy.

abther:Administering
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibioticTherapy#>;
	rdfs:label """antibiotic administering"""@en;
	skos:definition """Administering an antibiotic to a patient."""@en;
	rdfs:subClassOf drug:Administering, [
		a owl:Restriction; owl:onProperty event:hasObject; owl:someValuesFrom [ # drug:AdministrationForm
			a owl:Restriction; owl:onProperty space:contains; owl:someValuesFrom [ # drug:Product/drug:Compound
				a owl:Restriction; owl:onProperty drug:hasActivePart; owl:someValuesFrom [ # drug:Substance
					a owl:Restriction; owl:onProperty agent:playsRole; owl:someValuesFrom abther:Antibiotic]]]];
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "68322007"^^clisko:sct20080731DT].

abther:Antibiotic
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibioticTherapy#>;
	rdfs:label """antibiotic"""@en;
	skos:definition """Role of a substance killing or inhibiting the growth of bacteria."""@en;
	rdfs:subClassOf drug:Role;
	skos:exactMatch [
		a skos:Concept; skos:inScheme clisko:sct20080731; skos:notation "255631004"^^clisko:sct20080731DT].

abther:BroadSpectrum
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibioticTherapy#>;
	rdfs:label """broad-spectrum antibiotic"""@en;
	skos:definition """Role of an antibiotic active against a range of bacteria species, and both Gram-positive and Gram-negative bacteria."""@en;
	rdfs:subClassOf abther:Antibiotic.

abther:NarrowSpectrum
	a rdfs:Class;
	rdfs:isDefinedBy <http://www.agfa.com/w3c/2009/antibioticTherapy#>;
	rdfs:label """narrow-spectrum antibiotic"""@en;
	skos:definition """Role of an antibiotic active against specific families of bacteria."""@en;
	rdfs:subClassOf abther:Antibiotic.